| The effect of fructose on fructose 2,6-bisphosphate level and fructose 6-phosphate, 2-kinase activity in the perfused rat liver. | |
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MedLine Citation:
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PMID: 8395275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to investigate the effect of fructose on the metabolic rates of liver glycolysis, changes in fructose 2,6-bisphosphate content and fructose 6-phosphate, 2-kinase (F6P2kinase) activity were examined using perfused rat liver. When the starved liver was perfused with 0.5 mM fructose, the fructose 2,6-bisphosphate level was 6.66 nmol/g liver, or the maximum. However, with further increases in the fructose concentration, increments in the fructose 2,6-bisphosphate level gradually decreased. F6P2kinase was inactive in the starved rat liver. By perfusion with the medium containing fructose or even without fructose, however, the enzyme was activated. The suppression of the increase in the fructose 2,6-bisphosphate level by perfusion at higher fructose concentrations was at least partly due to the inhibition of F6P2kinase by F1P. |
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Authors:
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A Ogawa; T Nishi; E Furuya; F Watanabe; A Sakai; Y Kido; T Tsujinaka; T Mori |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemistry and molecular biology international Volume: 30 ISSN: 1039-9712 ISO Abbreviation: Biochem. Mol. Biol. Int. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-09-27 Completed Date: 1993-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306673 Medline TA: Biochem Mol Biol Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 83-90 Citation Subset: IM |
Affiliation:
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Second Department of Surgery, Osaka University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Chromatography, High Pressure Liquid Fructose / pharmacology* Fructosediphosphates / metabolism* Fructosephosphates / metabolism Liver / drug effects, enzymology, metabolism* Male Perfusion Phosphofructokinase-2 Phosphotransferases / metabolism* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Fructosediphosphates; 0/Fructosephosphates; 15978-08-2/fructose-1-phosphate; 30237-26-4/Fructose; 56-65-5/Adenosine Triphosphate; 79082-92-1/fructose 2,6-diphosphate; EC 2.7.-/Phosphotransferases; EC 2.7.1.105/Phosphofructokinase-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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