Document Detail

The effect of frequent whole blood donation on ferritin, hepcidin, and subclinical atherosclerosis.
MedLine Citation:
PMID:  23043255     Owner:  NLM     Status:  Publisher    
BACKGROUND: Iron catalyzes the formation of free radicals, which could lead to damaged vascular walls and subsequent atherosclerosis. Blood donation decreases iron stores and can thus decrease cardiovascular risk. Even within blood donors, differences in stored iron are observed. This study investigates whether increasing lifetime number of donations decreases the extent of subclinical atherosclerosis within blood donors. STUDY DESIGN AND METHODS: Subclinical atherosclerosis was evaluated in 269 blood donors by measuring intima-media thickness (IMT), pulse-wave velocity (PWV), and ankle-brachial index (ABI). Lifetime number of whole blood donations was categorized into sex-specific donation tertiles. RESULTS: Ferritin and hepcidin were lower in high-frequency donors compared to low-frequency donors. Donors in the third sex-specific donation tertile had on average a 0.3% (95% confidence interval [CI], -3.6 to +3.0%) lower IMT, a 2.1% (95% CI, -3.9 to +8.0%) higher PWV, and a 1.5% (95% CI, -1.4 to +4.5%) higher ABI compared to donors in the first sex-specific donation tertile. CONCLUSION: With such small differences and no consistent trend across donation groups, it cannot be concluded that blood donation has a beneficial effect on the extent of subclinical atherosclerosis.
Karlijn Peffer; Martin den Heijer; Suzanne Holewijn; Jacqueline de Graaf; Dorine W Swinkels; André L M Verbeek; Femke Atsma
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-9
Journal Detail:
Title:  Transfusion     Volume:  -     ISSN:  1537-2995     ISO Abbreviation:  Transfusion     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 American Association of Blood Banks.
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