Document Detail

The effect of food intake on the pharmacokinetics of sustained-release morphine sulfate capsules.
MedLine Citation:
PMID:  9152568     Owner:  NLM     Status:  MEDLINE    
The effect of food intake on the pharmacokinetics of sustained-release (SR) morphine sulfate capsules was assessed in 24 healthy male volunteers. Subjects were randomized to receive a single, 20-mg SR morphine sulfate capsule while fasting and immediately after consumption of a standard high-fat meal. Plasma samples were masked for pharmacokinetic analysis. Although the extent of absorption of the SR preparation was comparable in subjects in the fed and fasted states, plasma morphine concentrations were significantly lower at most sampling times up to 10 hours when the drug was administered after a high-fat meal. The rate of absorption of morphine from the SR capsule was slower with food intake as evidenced by a 13% decrease in the maximum concentration (Cmax), a 28% increase in the half-life of absorption, and a 19% increase in the time to Cmax. Results of this study indicate that food intake had an effect on the overall plasma-concentration-versus-time profile of the SR morphine sulfate oral preparation, the extent of which was not revealed by a comparison of Cmax and area under the plasma concentration-time curve values alone.
R F Kaiko
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical therapeutics     Volume:  19     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:    1997 Mar-Apr
Date Detail:
Created Date:  1997-06-11     Completed Date:  1997-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  296-303     Citation Subset:  IM    
Medical Department, Purdue Frederick Company, Norwalk, Connecticut, USA.
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MeSH Terms
Analgesics, Opioid / adverse effects,  blood,  pharmacokinetics*
Area Under Curve
Delayed-Action Preparations
Intestinal Absorption
Morphine / adverse effects,  blood,  pharmacokinetics*
Reg. No./Substance:
0/Analgesics, Opioid; 0/Capsules; 0/Delayed-Action Preparations; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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