Document Detail


The effect of food and ice cream on the adsorption capacity of paracetamol to high surface activated charcoal: in vitro studies.
MedLine Citation:
PMID:  14629735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of added food mixture (as if food was present in the stomach of an intoxicated patient) or 4 different types of ice cream (added as a flavouring and lubricating agent) on the adsorption of paracetamol (acetaminophen) to 2 formulations of activated charcoal was determined in vitro and compared with results from previous investigations showing a maximum adsorption capacity to the two activated charcoal-water slurries at about 0.62-0.72 g paracetamol/g activated charcoal. Activated charcoal (Carbomix or Norit Ready-To-Use), simulated gastric (pH 1.2) or intestinal (pH 7.2) fluid, and paracetamol were mixed with either food mixture or ice cream followed by one hr incubation. The maximum adsorption capacity of paracetamol to activated charcoal was calculated using Langmuirs adsorption isotherm. Paracetamol concentration was analyzed using high pressure liquid chromatography. In the presence of food, the paracetamol adsorption capacity of the 2 activated charcoals was reduced by max. 19% (P<0.05) for Carbomix(R) and by max. 11% (P<0.05) for Norit Ready-to-use compared to control without food (Hoegberg et al. 2002). Depending on which type of ice cream was mixed with the charcoal, the reductions compared to control (Hoegberg et al. 2002) varied between 11% and 26%. Even though a reduction in drug adsorption to activated charcoal was observed when food mixture or ice cream was added, the remaining adsorption capacity of both types of activated charcoal theoretically was still able to provide an effective gastrointestinal decontamination.
Authors:
Lotte Christine Groth Hoegberg; Helle Riis Angelo; Anne Bolette Christophersen; Hanne Rolighed Christensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology & toxicology     Volume:  93     ISSN:  0901-9928     ISO Abbreviation:  Pharmacol. Toxicol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702180     Medline TA:  Pharmacol Toxicol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Affiliation:
Departments of Clinical Biochemistry and Clinical Pharmacology, Bispebjerg Hospital, DK-2300 Copenhagen S, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / chemistry*
Adsorption
Analgesics, Non-Narcotic / chemistry*
Charcoal / chemistry*
Chromatography, High Pressure Liquid
Food*
Food-Drug Interactions
Hydrogen-Ion Concentration
Ice Cream
Surface Properties
Yogurt
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen; 16291-96-6/Charcoal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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