Document Detail

The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial.
MedLine Citation:
PMID:  19201496     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Observational studies have suggested a causal relationship between hyperhomocysteinemia and cardiovascular complications such as stroke and ischemic heart disease. The Homocysteine Lowering Trialists' Collaboration has shown that daily administration of folic acid can significantly decrease homocysteine levels up to 25%. Aim of this study was to investigate the effect of daily supplementation of folic acid (5 mg) on IMT after 18 months of treatment in patients with at least one cardiovascular risk factor. METHODS: We enrolled 103 patients with at least one cardiovascular risk factor who were randomized to receive either a daily dose of 5 mg folic acid (group I, n=53) or placebo (group II, n=50) for 18 months. RESULTS: After 18 months of folic acid supplementation, homocysteine levels were significantly reduced in the active treatment group compared to a non-significant increase in the placebo group. Folic acid levels were markedly increased in the former group and non-significantly reduced in the latter. Significant regression of carotid IMT was observed (0.961+/-0.092 to 0.933+/-0.077 mm, p<0.001) compared to significant IMT progression in the placebo group (0.964+/-0.099 to 0.984+/-0.094 mm). CONCLUSION: Folic acid supplementation results in significant IMT reduction after 18 months in patients with at least one cardiovascular risk.
George Ntaios; Christos Savopoulos; Dimitrios Karamitsos; Ippoliti Economou; Evangelos Destanis; Ioannis Chryssogonidis; Ifigenia Pidonia; Pantelis Zebekakis; Christos Polatides; Michael Sion; Dimitrios Grekas; Apostolos Hatzitolios
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-02-08
Journal Detail:
Title:  International journal of cardiology     Volume:  143     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  16-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University, Thessaloniki, Greece.
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MeSH Terms
Carotid Artery Diseases / drug therapy*,  epidemiology*,  ultrasonography
Folic Acid / administration & dosage*,  blood
Homocysteine / blood
Hyperhomocysteinemia / drug therapy*,  epidemiology*
Risk Factors
Tunica Intima / ultrasonography
Tunica Media / ultrasonography
Vitamin B Complex / administration & dosage*,  blood
Reg. No./Substance:
0/Placebos; 12001-76-2/Vitamin B Complex; 454-28-4/Homocysteine; 59-30-3/Folic Acid
Comment In:
Int J Cardiol. 2010 Oct 8;144(2):326-8   [PMID:  19324433 ]

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