Document Detail


The effect of flosequinan in patients with acute-onset heart failure complicating acute myocardial infarction.
MedLine Citation:
PMID:  2614925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the hemodynamic effect of a single dose of the new direct-acting vasodilator, flosequinan, in 25 patients with severe acute-onset heart failure complicating acute myocardial infarction, which was resistant to high doses of diuretics, nitrates and dobutamine given intravenously. Flosequinan was added to conventional therapy within 3.7 +/- 0.8 days of the infarction in the form of a single oral dose of 100 mg. Hemodynamic monitoring was performed every hour for 4 hours after the administration, without any other drug being added. Flosequinan produced hemodynamic improvement in all patients. The effect peaked at 1 to 2 hours and remained at this level at 4 hours. Pulmonary capillary wedge pressure decreased from 28.4 +/- 4.5 to 17.8 +/- 5.7 mmHg and cardiac output increased from 3.5 +/- 0.3 to 4.0 +/- 0.4 L/min (p less than 0.05 for both). Pulmonary arterial and pulmonary vascular resistances were also significantly reduced. Heart rate was not significantly altered. Mean systemic arterial pressure was slightly but not significantly reduced. Administration of flosequinan was not associated with symptomatic hypotension, cardiac arrhythmias or other adverse events and the hemodynamic effect was not related to the pre-treatment serum sodium concentration. We conclude that flosequinan is effective in producing acute hemodynamic improvement in patients with heart failure complicating acute myocardial infarction which is resistant to conventional therapy. Flosequinan is well tolerated in this group of patients and therefore further studies to determine the duration of action of the drug in this condition are appropriate.
Authors:
A Schneeweiss; R D Wynne; A Marmor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  30     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  627-34     Citation Subset:  IM    
Affiliation:
Geriatric Cardiology Research Foundation, Geneva, Tel-Aviv, Israel.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Cardiac Output / drug effects
Drug Evaluation
Female
Heart Failure / drug therapy*,  etiology,  physiopathology
Hemodynamics / drug effects
Humans
Male
Middle Aged
Myocardial Infarction / complications*
Pulmonary Circulation / drug effects
Pulmonary Wedge Pressure / drug effects
Quinolines / therapeutic use*
Vascular Resistance / drug effects
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Quinolines; 0/Vasodilator Agents; 76568-02-0/flosequinan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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