| The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. | |
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MedLine Citation:
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PMID: 1657368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since lignans have been suggested to have some cancer-protective effects, flaxseed, the most abundant source of lignan precursors, was tested for its effect on early markers of risk for mammary carcinogenesis. Supplementation of a high-fat diet with flaxseed flour (FF) or defatted flaxseed meal (FM) (5% or 10%) reduced the epithelial cell proliferation by 38.8-55.4% and nuclear aberrations by 58.8-65.9% in female rat mammary gland, with optimum effects seen with the 5% FF. These protective effects were accompanied by increases in urinary lignan excretion indicating that they may be related to the ability of flaxseed to provide lignan precursors. |
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Authors:
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M Serraino; L U Thompson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer letters Volume: 60 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1991-12-02 Completed Date: 1991-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 135-42 Citation Subset: IM |
Affiliation:
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Department of Nutritional Sciences, University of Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Phytogenic Cell Division / drug effects Dose-Response Relationship, Drug Epithelium / pathology Female Lignans Lignin / pharmacology* Mammary Neoplasms, Animal / diet therapy, prevention & control* Mutation / drug effects Rats Rats, Inbred Strains Regression Analysis Tumor Markers, Biological Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Lignans; 0/Tumor Markers, Biological; 9005-53-2/Lignin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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