| The effect of fibrinogen genotype on fibrinogen levels after strenuous physical exercise. | |
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MedLine Citation:
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PMID: 11858186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined the effect of two beta-fibrinogen gene promoter polymorphisms (-455G>A and -854G>A) on the fibrinogen response to severe exercise in a group of male army recruits undergoing basic training. Fibrinogen was measured pre-training and again serially after severe 48 h final military exercise (FME). Out of 884 subjects, 762 completed training of whom 250 were selected for post-FME study. Fibrinogen levels (g/l) were significantly elevated over baseline levels 2, 48 and 96 h after FME, representing increases of 15.7%, 3.4% and 7.6% (p <0.005; p = 0.05 and p <0.005 respectively), with higher levels in -455A allele carriers than genotype -455GG: 3.17+/-0.05 vs. 2.94+/-0.05 (p <0.001), 2.86+/-0.05 vs. 2.60+/-0.05 (p <0.0005) and 2.98+/-0.06 vs. 2.69+/-0.06 (p <0.0005) at 2, 48 and 96 h respectively. There was no effect of the -854G>A polymorphism on fibrinogen, even after taking into account beta-fibrinogen -455 genotype. Thus the fibrinogen -455G>A polymorphism influences fibrinogen levels following exercise. The effect of genotype might be clinically relevant at times of hyperfibrinogenaemia such as following an acute inflammatory response. |
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Authors:
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D J Brull; S Dhamrait; R Moulding; A Rumley; G D O Lowe; M J World; S E Humphries; H E Montgomery |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 87 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-02-18 Completed Date: 2002-08-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
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Languages: eng Pagination: 37-41 Citation Subset: IM |
Affiliation:
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Department of Medicine, Royal Free and UCL Medical School, UK. d.brull@ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Reaction Adult Cohort Studies Exercise / physiology* Fibrinogen / analysis*, genetics* Genotype Humans Male Military Personnel Polymorphism, Genetic Promoter Regions, Genetic / genetics* Protein Subunits |
| Chemical | |
Reg. No./Substance:
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0/Protein Subunits; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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