Document Detail

The effect of fibrin clot on healing rat supraspinatus tendon defects.
MedLine Citation:
PMID:  12070496     Owner:  NLM     Status:  MEDLINE    
The possibility that fibrin clot, with its chemotactic and mitogenic factors, might improve the healing of a defect in the rat supraspinatus tendon was evaluated. Bilateral defects were surgically created in the rat supraspinatus tendon near the humeral insertion. One defect in each rat was filled with fibrin clot from a donor animal while the other side acted as a control. The tendons were evaluated at 3, 6, and 12 weeks. On histologic evaluation persistent defects were seen at all time points, whereas the healing tissue became less cellular with better collagen organization over time. Fibrin clot remained in the healing defects of treated shoulders at early time points. Biomechanically, there was improvement of properties over time, but they did not approach those of normal tendon by 12 weeks. There was no effect from addition of the fibrin clot except at 3 weeks, where it led to a decrease in material properties.
Stavros Thomopoulos; Louis J Soslowsky; Colleen L Flanagan; Sovanrith Tun; Colby C Keefer; Jerry Mastaw; James E Carpenter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.]     Volume:  11     ISSN:  1058-2746     ISO Abbreviation:  J Shoulder Elbow Surg     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-06-18     Completed Date:  2002-09-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9206499     Medline TA:  J Shoulder Elbow Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-47     Citation Subset:  IM    
Orthopaedic Research Laboratories, University of Michigan, Ann Arbor, MI, USA.
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MeSH Terms
Fibrin Tissue Adhesive
Rats, Sprague-Dawley
Shoulder / injuries*
Tendon Injuries / pathology,  surgery*
Wound Healing
Grant Support
Reg. No./Substance:
0/Fibrin Tissue Adhesive; 9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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