Document Detail

The effect of fetal urine on the development of the bowel in gastroschisis.
MedLine Citation:
PMID:  6834226     Owner:  NLM     Status:  MEDLINE    
A gastroschisis model was successfully developed in the chicken embryo. The embryologic anatomy of this laboratory animal enabled the inducement of an abdominal wall defect, whereby the eviscerated abdominal contents were not exposed to fetal urine. A total of 999 embryos underwent a surgical intervention at an early developmental stage, from the 5th-8th day of the incubation period. Twenty-four hour mortality was 7%. Surgery carried out on the 5th day resulted in the largest number of survivors, 25% of the induced lesions had healed and gastroschisis did not occur. The characteristic picture of gastroschisis only evolved when the herniated bowel was exposed to urine components. Histologic studies were carried out with the aid of various staining techniques to determine the development and distribution of the enteric ganglia in experimental gastroschisis. Contrary to similar studies that would point to damage of enteric ganglion cells as being responsible for the delay in intestinal motility, no ganglionic injury was noted in our bowel studies.
P Klück; D Tibboel; A W van der Kamp; J C Molenaar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  18     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  47-50     Citation Subset:  IM    
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MeSH Terms
Chick Embryo
Disease Models, Animal
Hernia, Ventral / embryology*,  physiopathology,  surgery
Intestines / embryology*,  growth & development,  surgery

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