Document Detail

The effect of externally applied subatmospheric pressure on serum myoglobin levels after a prolonged crush/ischemia injury.
MedLine Citation:
PMID:  12352493     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with injuries that cause significant muscle death often develop rhabdomyolysis. The subsequent release and entry of myoglobin into the systemic circulation leads to myoglobinuria, renal injury, and potentially acute renal failure. METHODS: Large (5 kg) adult rabbits (n = 8) were anesthetized and a 15-kg weight placed on the posterior compartment for 4 hours. After this time, the weight was removed and releasing incisions were made. Subatmospheric pressure (125 mm Hg) was continuously applied to the wounds of four rabbits. Systemic serum samples were obtained at the time of weight removal and at 2, 4, and 8 hours postremoval, and were analyzed for myoglobin content. RESULTS: Serum myoglobin levels were similar for both groups at the time of weight removal. Serum myoglobin levels demonstrated a progressive increase with time in nontreated animals, and were significantly elevated compared with subatmospheric pressure-treated animals at all time points (p < 0.001). CONCLUSION: This study shows that application of subatmospheric pressure to an affected body part is associated with lower serum myoglobin levels.
Michael J Morykwas; Hampton Howell; Anthony J Bleyer; Joseph A Molnar; Louis C Argenta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of trauma     Volume:  53     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-27     Completed Date:  2002-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  537-40     Citation Subset:  AIM; IM    
Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
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MeSH Terms
Compartment Syndromes / blood*
Disease Models, Animal
Hindlimb / blood supply
Kidney Failure, Acute / blood*
Muscle, Skeletal / blood supply,  injuries*
Myoglobin / blood*
Rhabdomyolysis / blood*
Reg. No./Substance:

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