Document Detail

The effect of experimental pleurodesis caused by aluminum hydroxide on lung and chest wall mechanics.
MedLine Citation:
PMID:  11976897     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the effect of a chemical sclerosing agent, aluminum hydroxide, on pleural remodeling and on respiratory mechanics in rats. Saline (2 mL) or aluminum hydroxide [2 mL (0.15 g/mL)] was instilled intrapleurally in anesthetized male rats. The animals were studied 7 or 30 days after the instillation. Respiratory system, lung, and chest wall elastic, resistive, and viscoelastic/inhomogeneous pressures were measured by the end-inflation occlusion method. We studied the pleural remodeling process by means of semiquantitative analysis of the induced inflammation and quantitative analysis of the collagen extracellular matrix component. The effects on the underlying lung were analyzed morphometrically. Chest wall elastic and viscoelastic pressures increased after aluminum hydroxide instillation independent of time after instillation. Pleural inflammation was observed 7 days after instillation, while pleural adherence with a marked increase in the type I/type III collagen ratio was present 30 days after instillation. Histological examination demonstrated no differences in lung parenchyma among the groups. In conclusion, the present model describes the establishment of pleurodesis by aluminum hydroxide, which thwarts the normal chest wall mechanical profile without inducing any changes in the underlying lungs. The results were disclosed by both mechanical and morphological evaluation of the pleural remodeling.
D A Albuquerque; V R Seidl; V C Santos; J A Oliveira-Neto; V L Capelozzi; P R Rocco; W A Zin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lung     Volume:  179     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  2001  
Date Detail:
Created Date:  2002-04-26     Completed Date:  2002-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-303     Citation Subset:  IM    
Laboratory of Respiration Physiology, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Brazil.
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MeSH Terms
Aluminum Hydroxide / administration & dosage*
Pleura / physiopathology
Rats, Wistar
Respiratory Mechanics / drug effects*
Sclerosing Solutions / administration & dosage*
Reg. No./Substance:
0/Sclerosing Solutions; 21645-51-2/Aluminum Hydroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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