Document Detail

The effect of exogenous gonadotropic hormones on the endometrium of the rat.
MedLine Citation:
PMID:  2514174     Owner:  NLM     Status:  MEDLINE    
This investigation examined the effects of hyperstimulation on the uterine endometrium of rats. Female rats were injected, out of cycle, with FSH followed by hCG and mated. Control rats were mated during oestrus. Animals were killed at 5.5 days of pregnancy. The endometrium was examined by light and electron microscopy. Hyperstimulation resulted in an increase in the length and number of microvilli and a deficiency of the glycocalyx of surface epithelial cells. Stromal cells failed to undergo decidualization. These alterations in morphology may interfere with attachment and implantation of the embryo.
B Stein; B Kramer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of anatomy     Volume:  164     ISSN:  0021-8782     ISO Abbreviation:  J. Anat.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1990-02-21     Completed Date:  1990-02-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  123-30     Citation Subset:  IM    
Department of Anatomy, University of the Witwatersrand, Johannesburg, South Africa.
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MeSH Terms
Embryo Implantation / drug effects
Endometrium / cytology,  drug effects*,  ultrastructure
Follicle Stimulating Hormone / pharmacology
Gonadotropins / pharmacology*
Luteinizing Hormone / pharmacology
Microscopy, Electron
Rats, Inbred Strains
Reg. No./Substance:
0/Gonadotropins; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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