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The effect of exercise on urine albuminuria excretion in diabetic subjects.
MedLine Citation:
PMID:  21854502     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Spot urine measurement of albumin is now the most commonly accepted approach to screening for proteinuria. Exertion prior to the collection may potentially influence the result of spot urine albumin estimation. We aim to evaluate the effect of exercise on albuminuria in subjects at various stages of diabetic nephropathy in comparison to healthy control volunteers. Methods:  Thirty-Five diabetic subjects (19 with normoalbuminuria (NA), 9 with microalbuminuria (MA) and 7 with overt proteinuria (OP)) and nine control subjects were assessed. A 1km treadmill walk was performed. Four Spot urine specimens were collected; first morning void, immediately prior to exercise, and 1 and 2hours after exercise. A random effects linear regression mixed model was used to assess the effect of exercise on uACR. Results are presented separately for males and female diabetic subjects due to a significant exercise/gender interaction (p<0.05). Results:  No significant effect of exercise on uACR was seen in control subjects. In NA diabetic males no effect of exercise was seen while in females uACR 1hr post exercise was significantly higher than the early morning sample (3.55 mg/mmol (96% CI 0.27-6.83). Both female and male diabetes subjects with MA have increase in uACR 1hour post exercise (87.8, -24.3-199.4 & 6.7, 2.1-11.3). For both males and females with OP, uACR was significantly increased 1hour post exercise (67.5, 22-113 & 21.6, 8.4-34.8 respectively). In all groups uACR at 2hours post exercise was not significantly different to the early morning sample. Conclusions:  Exercise increased uACR estimation in normoalbuminuric subjects with diabetes with a larger effect in females. Whether exercise unmasks early diabetic nephropathy in NA subjects requires further study.
Authors:
Keng Hee Koh; Bolonghoge Dayanath; James C G Doery; Kevan R Polkinghorne; M Clin Epi; Helena Teede; Peter G Kerr
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-19
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Nephrology © 2011 Asian Pacific Society of Nephrology.
Affiliation:
Nephrology Fellow, Department of Nephrology, Clayton, Monash Medical Centre, Melbourne Consultant Nephrologist, Department of Medicine, Kuching Hospital, Malaysia Chemical Pathology Registrar, Department of Pathology, Monash Medical Centre, Clayton, Victoria Chemical Pathologist Department of Pathology, Monash Medical Centre, Clayton, Victoria & Senior Lecturer, Department of Medicine, Monash University Consultant Nephrologist Department of Nephrology, Monash Medical Centre and Monash University, Clayton, Victoria Head of Diabetes Unit - Southern Health Director of Research - Jean Hailes Research Group, Monash University, Clayton, Victoria Director and Consultant Nephrologist Department of Nephrology, Monash Medical Centre, and Monash University, Clayton Victoria.
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