Document Detail

The effect of exercise on trkA in the contralateral hemisphere of the ischemic rat brain.
MedLine Citation:
PMID:  20599809     Owner:  NLM     Status:  MEDLINE    
Activation of the trkA pathway has been widely accepted as a crucial factor for neuronal survival during cerebral ischemia. Findings from earlier studies have suggested that exercise changed neurotrophic factors and trk family in an ischemic rat model. In this study, we investigated the question of whether or not treadmill exercise improves motor function in an ischemic rat model, and whether or not the result is associated with trkA, responding to NGF. Adult male Sprague-Dawley rats underwent surgery for permanent ischemia, followed by either 12 days of treadmill exercise or non-exercise. We found that exercise increased the level of trkA and NGF proteins in the contralateral hemisphere and improved the motor behavior index. Our data indicate that treadmill exercise ameliorates motor performance via the elevation of trkA and NGF proteins in the contralateral hemisphere after permanent brain ischemia.
Jin-Young Chung; Min-Wook Kim; Moon-Suk Bang; Manho Kim
Related Documents :
9805099 - Skeletal muscle na+/h+ exchange in rats: ph dependency and the effect of training.
18957989 - Aging and sedentarism decrease vascularization and vegf levels in the rat substantia ni...
9309629 - Pre-exercise branched-chain amino acid administration increases endurance performance i...
23009189 - Study protocol: a randomised controlled trial of the effects of a multi-modal exercise ...
16586429 - Changes in the rat heart proteome induced by exercise training: increased abundance of ...
2144269 - Effect of thyroid state on cardiac myosin p-light chain phosphorylation during exercise.
1464659 - Heritability of cortisol responses to human corticotropin-releasing hormone, ergometry,...
20727209 - Nordic walking improves daily physical activities in copd: a randomised controlled trial.
2828449 - Mechanisms of acute increases in airway responsiveness caused by environmental chemicals.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-03
Journal Detail:
Title:  Brain research     Volume:  1353     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-03     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  187-93     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Department of Neurology, Seoul National University Hospital, Chongno-ku, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Brain Ischemia / pathology,  physiopathology*,  rehabilitation*
Disease Models, Animal
Exercise Test / methods
Functional Laterality / physiology*
Gene Expression Regulation / physiology*
Motor Activity / physiology
Nerve Growth Factor / genetics,  metabolism
Physical Conditioning, Animal / methods*
Protein-Tyrosine Kinases / genetics,  metabolism*
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
0/RNA, Messenger; 9061-61-4/Nerve Growth Factor; EC Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Role of olfactory bulb serotonin in olfactory learning in the greater short-nosed fruit bat, Cynopte...
Next Document:  A neural system for evaluating the behavioural relevance of salient events outside the current focus...