Document Detail


The effect of exercise on trkA in the contralateral hemisphere of the ischemic rat brain.
MedLine Citation:
PMID:  20599809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Activation of the trkA pathway has been widely accepted as a crucial factor for neuronal survival during cerebral ischemia. Findings from earlier studies have suggested that exercise changed neurotrophic factors and trk family in an ischemic rat model. In this study, we investigated the question of whether or not treadmill exercise improves motor function in an ischemic rat model, and whether or not the result is associated with trkA, responding to NGF. Adult male Sprague-Dawley rats underwent surgery for permanent ischemia, followed by either 12 days of treadmill exercise or non-exercise. We found that exercise increased the level of trkA and NGF proteins in the contralateral hemisphere and improved the motor behavior index. Our data indicate that treadmill exercise ameliorates motor performance via the elevation of trkA and NGF proteins in the contralateral hemisphere after permanent brain ischemia.
Authors:
Jin-Young Chung; Min-Wook Kim; Moon-Suk Bang; Manho Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-03
Journal Detail:
Title:  Brain research     Volume:  1353     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-03     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  187-93     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Neurology, Seoul National University Hospital, Chongno-ku, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Brain Ischemia / pathology,  physiopathology*,  rehabilitation*
Disease Models, Animal
Exercise Test / methods
Functional Laterality / physiology*
Gene Expression Regulation / physiology*
Male
Motor Activity / physiology
Nerve Growth Factor / genetics,  metabolism
Physical Conditioning, Animal / methods*
Protein-Tyrosine Kinases / genetics,  metabolism*
RNA, Messenger / metabolism
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/RNA, Messenger; 9061-61-4/Nerve Growth Factor; EC 2.7.10.1/Protein-Tyrosine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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