Document Detail

The effect of exercise training intensity on thyroid activity at rest.
MedLine Citation:
PMID:  9789797     Owner:  NLM     Status:  MEDLINE    
The influence of exercise training intensity on thyroid activity at rest was studied in male Wistar rats, weighting 114 g +/- 24 (mean +/- SD) at the beginning of the experiment. Animals were assigned to the following groups: untrained controls and rats trained on a treadmill at the speed of 20 m/min over a 5-week period with different intensities: 2 x 60 min weekly, 4 x 60 min, 6 x 20 min, 6 x 40 min and 6 x 60 min weekly. Thyroid peroxidase (TPO) and hepatic iodothyronine 5'-monodeiodinase (5'DI) activities as well as plasma thyroxine (T4), 3,3'5-triiodothyronine (T3) and 3,3'.5'-triiodothyronine (rT3) concentrations were determined. Training intensity was found to influence parameters under investigation. TPO activity was decreased in groups trained 240 min (4 x 60 min and 6 x 40 min) and 360 min (6 x 60 min) weekly in comparison to control, untrained group. Furthermore, a drop in T4 plasma concentration in all trained groups and a decrease in T3 plasma concentration in groups exercising for 120 min (2 x 60 min and 6 x 20 min) weekly, as compared to control, untrained rats, was found. Hepatic 5'DI activity and rT3 plasma concentration were not affected by training. Thus, exercise training in rats seems to elicit the fall in TPO activity and T4 plasma concentration at rest but without changing hepatic 5'DI activity and rT3 plasma concentrations. A decline in T3 plasma concentration, observed in rats trained with the lowest exercise intensities, cold be regarded as transitional effect in adaptation to chronic exercise.
D Rosołowska-Huszcz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  49     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  457-66     Citation Subset:  IM    
Department of Physiology of Nutrition, Faculty of Human Nutrition, Warsaw Agricultural University, Poland.
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MeSH Terms
Energy Metabolism
Iodide Peroxidase / analysis,  blood
Liver / enzymology
Physical Conditioning, Animal*
Rats, Wistar
Thyroid Gland / physiology*
Thyroid Hormones / blood
Weight Gain
Reg. No./Substance:
0/Thyroid Hormones; EC Peroxidase

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