| The effect of exercise on large artery haemodynamics in cystic fibrosis. | |
| | |
MedLine Citation:
|
PMID: 21220217 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Adult patients with cystic fibrosis (CF) have resting abnormal large artery haemodynamics. Here, we obtain further insight in patients with CF by evaluating haemodynamic response to physiological stress. METHODS: Thirty-six stable CF patients mean (SD) age 28.9 (9.0)years and 25 controls matched for age, gender and body mass index were studied. Central haemodynamic parameters; including augmentation index (AIx) and wasted left ventricular pressure energy (∆E(W)) were determined pre, during and post light intensity cycle ergometry. RESULTS: During exercise, despite a similar heart rate and blood pressure, patients had comparatively greater ∆E(W) (P=0.03) and trend towards greater AIx (P=0.07) than controls. Exercise ∆E(W) was greatest in patients with CF related diabetes (n=11). In all subjects, exercise ∆E(W) was related to age (r=0.54, P<0.001) and FEV(1)% predicted (r=-0.32, P=0.01). CONCLUSIONS: Adults with CF have an abnormal haemodynamic response to exercise. This finding has deleterious implications for myocardial performance. |
| | |
Authors:
|
James H Hull; Les Ansley; Charlotte E Bolton; James E Sharman; Ronald K Knight; John R Cockcroft; Dennis J Shale; Rachel Garrod |
Related Documents
:
|
1487337 - A comparison of the blood lactate and plasma catecholamine thresholds in untrained male... 21721967 - Physician advice on exercise and diet in a u.s. sample of obese mexican-american adults. 8856887 - Use of the relationship between blood lactate and running speed to determine the exerci... 21365527 - Somatostatin reduces neuropeptide y rise induced by physical exercise. 7705377 - Time course of haemodynamic changes after maximal exercise. 12370887 - Constraint-induced therapy for a child with hemiplegic cerebral palsy: a case report. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-8 |
Journal Detail:
|
Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Volume: - ISSN: 1873-5010 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101128966 Medline TA: J Cyst Fibros Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Faculty of Health and Social Care Sciences, Kingston University and St George's, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: KPC-2 Carbapenemase-producing Klebsiella pneumoniae isolates from patients with Cystic Fibrosis.
Next Document: Microarray-detected changes in gene expression in gills of green crabs (Carcinus maenas) upon diluti...