Document Detail

The effect of exercise intensity on the response to exercise rehabilitation in patients with intermittent claudication.
MedLine Citation:
PMID:  16242558     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this randomized trial was to compare the efficacy of a low-intensity exercise rehabilitation program vs a high-intensity program in changing physical function, peripheral circulation, and health-related quality of life in peripheral arterial disease (PAD) patients limited by intermittent claudication.
METHODS: Thirty-one patients randomized to low-intensity exercise rehabilitation and 33 patients randomized to high-intensity exercise rehabilitation completed the study. The 6-month exercise rehabilitation programs consisted of intermittent treadmill walking to near maximal claudication pain 3 days per week at either 40% (low-intensity group) or 80% (high-intensity group) of maximal exercise capacity. Total work performed in the two training regimens was similar by having the patients in the low-intensity group exercise for a longer duration than patients in the high-intensity group. Measurements of physical function, peripheral circulation, and health-related quality of life were obtained on each patient before and after the rehabilitation programs.
RESULTS: After the exercise rehabilitation programs, patients in the two groups had similar improvements in these measures. Initial claudication distance increased by 109% in the low-intensity group (P < .01) and by 109% in the high-intensity group (P < .01), and absolute claudication distance increased by 61% (P < 0.01) and 63% (P < .01) in the low-intensity and high-intensity groups, respectively. Furthermore, both exercise programs elicited improvements (P < .05) in peak oxygen uptake, ischemic window, and health-related quality of life.
CONCLUSION: The efficacy of low-intensity exercise rehabilitation is similar to high-intensity rehabilitation in improving markers of functional independence in PAD patients limited by intermittent claudication, provided that a few additional minutes of walking is accomplished to elicit a similar volume of exercise.
Andrew W Gardner; Polly S Montgomery; William R Flinn; Leslie I Katzel
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  42     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-24     Completed Date:  2005-12-01     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  702-9     Citation Subset:  IM    
CMRI Metabolic Research Center, University of Oklahoma Health Sciences Center, Oklahoma City 73117, USA.
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MeSH Terms
Exercise / physiology*
Exercise Test
Exercise Tolerance
Follow-Up Studies
Intermittent Claudication / diagnosis*,  rehabilitation*
Oxygen Consumption / physiology*
Peripheral Vascular Diseases / diagnosis,  rehabilitation
Physical Exertion
Quality of Life*
Regional Blood Flow
Risk Assessment
Severity of Illness Index
Treatment Outcome
Grant Support
K01-00657//PHS HHS; M01-RR-14467/RR/NCRR NIH HHS; P60-AG12583/AG/NIA NIH HHS; R01-AG-16685/AG/NIA NIH HHS

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