Document Detail


The effect of etomoxir on 24-h substrate oxidation and satiety in humans.
MedLine Citation:
PMID:  12081827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The carnitine O-palmitoyltransferase I (EC 2.3.1.21) inhibitor etomoxir inhibits fatty acid oxidation, and hepatic fatty acid oxidation has been suggested to be a metabolic satiety signal in subjects who consume high-fat diets. OBJECTIVE: We investigated substrate oxidation and satiety after repeated administrations of etomoxir or placebo in subjects who consumed a high-fat diet. DESIGN: In a randomized crossover design consisting of three 5-d treatments, we fed 10 healthy men [mean +/- SE age: 25.6 +/- 1.7 y; mean +/- SE body mass index (in kg/m(2)): 21.8 +/- 0.3] a high-fat diet twice and a low-fat diet once. The subjects consumed each diet at home for 3 consecutive days, after which they spent 36 h in energy balance in a respiration chamber. During the chamber stays with the high-fat treatments, etomoxir or placebo was administered in 5 doses (600 mg etomoxir in total). Blood samples were obtained on the mornings of days 4 and 5 of each treatment, and appetite profiles were assessed. RESULTS: Mean (+/-SE) 24-h respiratory quotients were significantly (P < 0.05) higher with repeated administrations of etomoxir (0.833 +/- 0.004) than with repeated administrations of placebo (0.814 +/- 0.006), and mean (+/-SE) 24-h whole-body fat oxidation tended to be less (13.7%, P = 0.06) with administration of etomoxir (136.0 +/- 5.2 g/d) than with administration of placebo (157.5 +/- 5.6 g/d). With the etomoxir treatment, fat balance was positive (P < 0.0001) and carbohydrate balance was negative (P < 0.001), whereas with the placebo treatment, neither of the balances was significantly different from zero. Hunger and satiety ratings were not affected under these conditions. CONCLUSIONS: Etomoxir decreased whole-body fat oxidation, as indicated by the respiratory quotients in the healthy subjects. With the current protocol, however, hunger and satiety ratings were not affected.
Authors:
Vera B Hinderling; Patrick Schrauwen; Wolfgang Langhans; Margriet S Westerterp-Plantenga
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  76     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-25     Completed Date:  2002-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  AIM; IM    
Affiliation:
Institute of Animal Sciences, Swiss Federal Institute of Technology, Zürich, Switzerland. vhi@rdia.azm.nl
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxybutyric Acid / blood
Adult
Blood Glucose / analysis
Body Mass Index
Carnitine O-Palmitoyltransferase / antagonists & inhibitors
Cross-Over Studies
Dietary Fats / administration & dosage
Energy Metabolism
Enzyme Inhibitors / pharmacology*
Epoxy Compounds / pharmacology*
Fatty Acids / blood,  metabolism*
Glycerol / blood
Humans
Hunger
Lactic Acid / blood
Male
Oxidation-Reduction
Placebos
Satiation / drug effects*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Fats; 0/Enzyme Inhibitors; 0/Epoxy Compounds; 0/Fatty Acids; 0/Placebos; 0/Triglycerides; 300-85-6/3-Hydroxybutyric Acid; 50-21-5/Lactic Acid; 56-81-5/Glycerol; 82258-36-4/etomoxir; EC 2.3.1.21/Carnitine O-Palmitoyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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