| The effect of estradiol-17 beta and actinomycin D on the release of PGF and PGE from separated cells of human endometrium. | |
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MedLine Citation:
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PMID: 3432558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Estradiol-17 beta selectively stimulated the release of PGF from separated glandular but not stromal cells of human secretory endometrium (p less than 0.025) but had no effect on PGF release from either type of cells obtained from proliferative endometrium. PGE release was not affected by estradiol-17 beta. Actinomycin D did not antagonise the effect of estradiol-17 beta on PGF release from secretory, glandular cells. Basal release of PGF from these cells was stimulated by actinomycin D alone (100 ng/ml) (p less than 0.025) and PGE release stimulated in the presence of estradiol-17 beta. Actinomycin D had no effect on PGF or PGE release from proliferative endometrium. These findings suggest that estradiol-17 beta stimulates PGF release by a mechanism that does not affect PGE release and which is not dependent on the synthesis of new protein. The basal release of PGF and PGE by glandular cells of secretory endometrium in vitro is regulated by protein/proteins which reduce PG release. |
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Authors:
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S K Smith; R W Kelly |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins Volume: 34 ISSN: 0090-6980 ISO Abbreviation: Prostaglandins Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1988-03-14 Completed Date: 1988-03-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0320271 Medline TA: Prostaglandins Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 553-61 Citation Subset: IM |
Affiliation:
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MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Separation Cells, Cultured Dactinomycin / pharmacology* Endometrium / cytology, drug effects*, metabolism Estradiol / pharmacology* Female Humans Prostaglandins E / metabolism* Prostaglandins F / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 0/Prostaglandins F; 50-28-2/Estradiol; 50-76-0/Dactinomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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