| The effect of esmolol-induced controlled hypotension in combination with acute normovolemic hemodilution on cerebral oxygenation. | |
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MedLine Citation:
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PMID: 16879470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is possible to perform acute normovolemic hemodilution (ANH) in combination with controlled hypotension (CH). In this randomized prospective study, we examined the effect of the combination of ANH and CH on cerebral oxygenation using near-infrared spectroscopy. METHODS: Fifty-six patients undergoing major orthopedic surgery were randomly assigned to either group A (ANH only) or group CH (CH in combination with ANH). In group CH, CH was induced with esmolol. The regional cerebral oxygen saturation (rSO(2)) was monitored continuously and was compared between the two groups before and after ANH, 30 min (OP(30)) and 90 min (OP(90)) after the beginning of surgery and after the completion of surgery. RESULTS: The value of rSO(2) was the same in both groups in the absence of CH (at baseline: group A, 70.1 +/- 6.0%; group CH, 69.9 +/- 6.7%; after surgery: group A, 64.5 +/- 4.9%; group CH, 64.3 +/- 5.8%). However, in the presence of CH, rSO(2) values were significantly lower in group CH than in group A (at OP(30): group A: 60.4 +/- 3.4%; group CH, 55.9 +/- 7.3%; P < 0.01; at OP(90): group A, 58.3 +/- 5.2%; group CH, 53.5 +/- 6.5%; P < 0.001). The number of patients with rSO(2) < 50% was significantly higher in group CH (14.3%) than in group A (3.8%). CONCLUSION: ANH in combination with esmolol-induced CH causes a significant decrease in cerebral oxygen saturation compared with ANH alone. |
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Authors:
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S-H Han; J-H Bahk; J-H Kim; Y-J Lim; C-D Park; S-H Do; Y-S Park |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 50 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-01 Completed Date: 2006-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: England |
Other Details:
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Languages: eng Pagination: 863-8 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Seoul National University, College of Medicine, 28 Yongon-Dong, Chongro-Gu, Seoul 110-744, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists Blood Volume* Brain / metabolism* Female Hemodilution* Humans Hypotension, Controlled* Male Middle Aged Orthopedic Procedures* Oxygen Consumption* Propanolamines / administration & dosage* Spectroscopy, Near-Infrared |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Propanolamines; 84057-94-3/esmolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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