| The effect of esmolol on the QTc interval during induction of anaesthesia in patients with coronary artery disease. | |
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MedLine Citation:
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PMID: 19302635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate whether esmolol has an effect on QT interval during induction of anaesthesia using etomidate and fentanyl in patients with known coronary artery disease. Sixty patients were prospectively randomised to either a control group or the esmolol group. Esmolol was administered as a bolus 1 mg.kg(-1), followed by a continuous infusion at 250 microg.kg(-1)min(-1). All patients received etomidate 0.3 mg.kg(-1) and fentanyl 15 microg.kg(-1). The ECG was recorded prior to induction of anaesthesia (T0), 5 min following the start of drug infusions (T1), 1 min following etomidate (T2), 3 min following vecuronium (T3), 30 s (T4), 2 min (T5) and 4 min (T6) after intubation. In the esmolol group, QTc interval was significantly shorter at T1, T2 and T4 compared to the control group (p < 0.05). In conclusion, QTc interval increased following tracheal intubation during induction of anaesthesia using etomidate and fentanyl. An infusion of Esmolol attenuated the QTc interval prolongation associated with tracheal intubation. |
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Authors:
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F Erdil; S Demirbilek; Z Begec; E Ozturk; A But; M Ozcan Ersoy |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anaesthesia Volume: 64 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-23 Completed Date: 2009-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 246-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesiology and Reanimation, School of Medicine, Inonu University, Malayta, Turkey. ferdil@inonu.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Aged Anesthesia, Intravenous / methods* Anesthetics, Intravenous Blood Pressure / drug effects Coronary Artery Bypass Coronary Artery Disease / physiopathology*, surgery Electrocardiography / drug effects* Etomidate Female Fentanyl Heart Rate / drug effects Humans Intubation, Intratracheal Male Middle Aged Propanolamines / pharmacology* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Anesthetics, Intravenous; 0/Propanolamines; 33125-97-2/Etomidate; 437-38-7/Fentanyl; 84057-94-3/esmolol |
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