Document Detail


The effect of esmolol on the QTc interval during induction of anaesthesia in patients with coronary artery disease.
MedLine Citation:
PMID:  19302635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate whether esmolol has an effect on QT interval during induction of anaesthesia using etomidate and fentanyl in patients with known coronary artery disease. Sixty patients were prospectively randomised to either a control group or the esmolol group. Esmolol was administered as a bolus 1 mg.kg(-1), followed by a continuous infusion at 250 microg.kg(-1)min(-1). All patients received etomidate 0.3 mg.kg(-1) and fentanyl 15 microg.kg(-1). The ECG was recorded prior to induction of anaesthesia (T0), 5 min following the start of drug infusions (T1), 1 min following etomidate (T2), 3 min following vecuronium (T3), 30 s (T4), 2 min (T5) and 4 min (T6) after intubation. In the esmolol group, QTc interval was significantly shorter at T1, T2 and T4 compared to the control group (p < 0.05). In conclusion, QTc interval increased following tracheal intubation during induction of anaesthesia using etomidate and fentanyl. An infusion of Esmolol attenuated the QTc interval prolongation associated with tracheal intubation.
Authors:
F Erdil; S Demirbilek; Z Begec; E Ozturk; A But; M Ozcan Ersoy
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  64     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-23     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  AIM; IM    
Affiliation:
Department of Anaesthesiology and Reanimation, School of Medicine, Inonu University, Malayta, Turkey. ferdil@inonu.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology*
Aged
Anesthesia, Intravenous / methods*
Anesthetics, Intravenous
Blood Pressure / drug effects
Coronary Artery Bypass
Coronary Artery Disease / physiopathology*,  surgery
Electrocardiography / drug effects*
Etomidate
Female
Fentanyl
Heart Rate / drug effects
Humans
Intubation, Intratracheal
Male
Middle Aged
Propanolamines / pharmacology*
Prospective Studies
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anesthetics, Intravenous; 0/Propanolamines; 33125-97-2/Etomidate; 437-38-7/Fentanyl; 84057-94-3/esmolol

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