| The effect of erythropoietin on exercise capacity, left ventricular remodeling, pressure-volume relationships, and quality of life in older patients with anemia and heart failure with preserved ejection fraction. | |
| | |
MedLine Citation:
|
PMID: 20557328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A prospective, open-label, 3-month study was conducted to evaluate the feasibility and short-term clinical effect of subcutaneous erythropoietin injections in patients with anemia and heart failure with preserved ejection fraction (ejection fraction, 55%+/-2%). Using a dose-adjusted algorithm to effect a rate of rise in hemoglobin not to exceed 0.4 g/dL /wk, hemoglobin (10.8+/-0.3 to 12.2+/-0.3 g/dL) and red blood cell volume (1187+/-55 to 1333+/-38 mL) increased with an average weekly dose of 3926 units. Functional measures increased from baseline (6-minute walk test [289+/-24 to 331+/-22 m], exercise time [432+/-62 to 571+/-51 s], and peak oxygen consumption [8.2+/-0.7 to 9.4+/-0.9 mL/kg/min], all P<.05). End-diastolic volume declined significantly (8% volumetric decrease, 108+/-3 to 100+/-3 mL, P =.03), but there were no significant changes in left ventricular mass or estimated left ventricular end-diastolic pressure. Pressure-volume analysis demonstrated a reduction in ventricular capacitance at an end-diastolic pressure of 30 mm Hg without significant changes in contractile state. |
| | |
Authors:
|
Rose S Cohen; Paula Karlin; Madeline Yushak; Donna Mancini; Mathew S Maurer |
Related Documents
:
|
2438948 - Contractility-dependent curvilinearity of end-systolic pressure-volume relations. 8376948 - Developmental changes in the acetylcholine influence on heart muscle of rana catesbeian... 1935158 - Systolic and diastolic time intervals in the critically ill patient. 3578548 - Transient vs. steady end-systolic pressure-volume relation in dog left ventricle. 8263888 - Prevalence of left ventricular hypertrophy as assessed by electrocardiogram in treated ... 15647778 - Aggressive antihypertensive therapy based on hydrochlorothiazide, candesartan or lisino... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Congestive heart failure (Greenwich, Conn.) Volume: 16 ISSN: 1751-7133 ISO Abbreviation: Congest Heart Fail Publication Date: 2010 May-Jun |
Date Detail:
|
Created Date: 2010-06-18 Completed Date: 2011-06-02 Revised Date: 2011-10-19 |
Medline Journal Info:
|
Nlm Unique ID: 9714174 Medline TA: Congest Heart Fail Country: United States |
Other Details:
|
Languages: eng Pagination: 96-103 Citation Subset: IM |
Copyright Information:
|
(c) 2009 Wiley Periodicals, Inc. |
Affiliation:
|
Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Psychological Aged Aged, 80 and over Algorithms Anemia / etiology* Cardiac Output Erythropoietin / therapeutic use* Exercise Tolerance / drug effects* Female Health Status Indicators Heart Failure / complications*, ultrasonography Hemodynamics Humans Male Middle Aged Oxygen Consumption Prospective Studies Quality of Life* Questionnaires Stroke Volume / drug effects Time Factors Ventricular Function, Left / drug effects Ventricular Remodeling* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 AG027518-04/AG/NIA NIH HHS; R01AG027518-01A1/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
11096-26-7/Erythropoietin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment of anemia with darbepoetin alfa in heart failure.
Next Document: Low-dose dobutamine stress echocardiography to assess left ventricular contractile reserve for cardi...