Document Detail


The effect of epsilon-aminocaproic acid on HemoSTATUS and kaolin-activated clotting time measurements.
MedLine Citation:
PMID:  10825308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
New point-of-care assays have been used to identify patients with heparin resistance (i.e. heparin dose response test; Medtronic Blood Management, Parker, CO) and who have platelet dysfunction (i.e. HemoSTATUS; Medtronic Blood Management). We examined the effect of epsilon-aminocaproic acid on results from these two point-of-care tests in patients undergoing cardiac surgery. Twenty patients scheduled for elective cardiac surgical procedures were enrolled in this prospective study. HemoSTATUS clot ratio (% maximal) values in Channels (Ch) 3-6 (Ch 3: 26 +/- 25, Ch 4: 66 +/- 23, Ch 5: 84 +/- 20, Ch 6: 106 +/- 18) obtained after the IV administration of epsilon-aminocaproic acid were similar to values obtained before the administration of this agent (Ch 3: 26 +/- 20, Ch 4: 69 +/- 23, Ch 5: 86 +/- 19, Ch 6: 109 +/- 14). Slope values (86 +/- 23 s x U(-1) x mL(-1)) and projected heparin concentrations (4 +/- 1 U/mL) obtained before the administration of epsilon-aminocaproic acid were similar to slope values (88 +/- 21 s x U(-1) x mL(-1)) and projected heparin concentrations (4 +/- 1 U/mL) values obtained after administration of this agent. Our data indicate that HemoSTATUS clot ratio values and heparin dose response values are not significantly affected after IV dosing of epsilon-aminocaproic acid. Implications: Values from two activated coagulation time-based test systems used to identify significant heparin resistance or platelet dysfunction after cardiopulmonary bypass were not significantly affected by epsilon-aminocaproic acid administered IV.
Authors:
R Saleem; M Bigham; E Spitznagel; G J Despotis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  90     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-06-16     Completed Date:  2000-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1281-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
6-Aminocaproic Acid / pharmacology*
Aged
Antifibrinolytic Agents / pharmacology*
Aspirin / pharmacology
Blood Coagulation / drug effects*
Cardiac Surgical Procedures
Female
Fibrin / drug effects
Humans
Kaolin / diagnostic use*
Male
Platelet Aggregation Inhibitors / pharmacology
Platelet Function Tests*
Whole Blood Coagulation Time*
Chemical
Reg. No./Substance:
0/Antifibrinolytic Agents; 0/Platelet Aggregation Inhibitors; 1332-58-7/Kaolin; 50-78-2/Aspirin; 60-32-2/6-Aminocaproic Acid; 9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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