| The effect of epsilon-aminocaproic acid on HemoSTATUS and kaolin-activated clotting time measurements. | |
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MedLine Citation:
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PMID: 10825308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New point-of-care assays have been used to identify patients with heparin resistance (i.e. heparin dose response test; Medtronic Blood Management, Parker, CO) and who have platelet dysfunction (i.e. HemoSTATUS; Medtronic Blood Management). We examined the effect of epsilon-aminocaproic acid on results from these two point-of-care tests in patients undergoing cardiac surgery. Twenty patients scheduled for elective cardiac surgical procedures were enrolled in this prospective study. HemoSTATUS clot ratio (% maximal) values in Channels (Ch) 3-6 (Ch 3: 26 +/- 25, Ch 4: 66 +/- 23, Ch 5: 84 +/- 20, Ch 6: 106 +/- 18) obtained after the IV administration of epsilon-aminocaproic acid were similar to values obtained before the administration of this agent (Ch 3: 26 +/- 20, Ch 4: 69 +/- 23, Ch 5: 86 +/- 19, Ch 6: 109 +/- 14). Slope values (86 +/- 23 s x U(-1) x mL(-1)) and projected heparin concentrations (4 +/- 1 U/mL) obtained before the administration of epsilon-aminocaproic acid were similar to slope values (88 +/- 21 s x U(-1) x mL(-1)) and projected heparin concentrations (4 +/- 1 U/mL) values obtained after administration of this agent. Our data indicate that HemoSTATUS clot ratio values and heparin dose response values are not significantly affected after IV dosing of epsilon-aminocaproic acid. Implications: Values from two activated coagulation time-based test systems used to identify significant heparin resistance or platelet dysfunction after cardiopulmonary bypass were not significantly affected by epsilon-aminocaproic acid administered IV. |
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Authors:
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R Saleem; M Bigham; E Spitznagel; G J Despotis |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 90 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-06-16 Completed Date: 2000-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1281-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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6-Aminocaproic Acid
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pharmacology* Aged Antifibrinolytic Agents / pharmacology* Aspirin / pharmacology Blood Coagulation / drug effects* Cardiac Surgical Procedures Female Fibrin / drug effects Humans Kaolin / diagnostic use* Male Platelet Aggregation Inhibitors / pharmacology Platelet Function Tests* Whole Blood Coagulation Time* |
| Chemical | |
Reg. No./Substance:
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0/Antifibrinolytic Agents; 0/Platelet Aggregation Inhibitors; 1332-58-7/Kaolin; 50-78-2/Aspirin; 60-32-2/6-Aminocaproic Acid; 9001-31-4/Fibrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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