| The effect of enterohemorrhagic Escherichia coli O157:H7 on intestinal structure and solute transport in rabbits. | |
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MedLine Citation:
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PMID: 8425689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effect of enterohemorrhagic Escherichia coli O157:H7 infection on intestinal morphology and solute transport was examined. METHODS: New Zealand white rabbits, aged 10 days, were infected with E. coli strain EDL933 (O157:H7 containing the 60-megadalton plasmid-encoding adhesion factors VT1 and VT2) and compared with controls. Small and large intestinal histology and solute transport were studied 5 days after inoculation. Ion transport in the distal colon was also examined in animals infected with different strains encoding a combination of pathogenic factors. RESULTS: Infection with EDL933 induced diarrhea and mucosal disease in the colon, inhibited colonic Na+ absorption, and stimulated of Cl- secretion, but had no impact on the small intestine. Infection with strains A7785-C3A (O157:H7, plasmid-, VT1+, VT2+) and 85-170 (O157:H7, plasmid+, VT-) induced similar transport changes to EDL933. C600/1 (E. coli K-12, plasmid+, VT1+) decreased Na+ and Cl- absorption only. CONCLUSIONS: Abnormalities of colonic structure and ion transport could account for diarrhea production, but pathogenic factors other than the 60-megadalton plasmid-encoding adhesion factor and verotoxins appear to be involved in enterohemorrhagic E. coli infection. |
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Authors:
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Z Li; C Bell; A Buret; R Robins-Browne; D Stiel; E O'Loughlin |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterology Volume: 104 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-02-26 Completed Date: 1993-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 467-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics and Child Health, Children's Hospital, Camperdown, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chlorides / metabolism* Colon / metabolism, pathology Disease Models, Animal Escherichia coli Infections / metabolism*, pathology* Ileum / metabolism Intestinal Mucosa / pathology* Ion Transport Rabbits Sodium / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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