| The effect of endurance training on exercise capacity following cardiac resynchronization therapy in chronic heart failure patients: a pilot trial. | |
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MedLine Citation:
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PMID: 17301634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Both endurance training (ET) and cardiac resynchronization therapy (CRT) improve quality of life (QOL) and exercise tolerance in patients with advanced chronic heart failure (CHF). DESIGN: A randomized intervention trial to study the effect on exercise capacity of ET in addition to CRT in patients with CHF and dyssynchrony. METHODS: Seventeen patients (eight men, aged 59+/-9 years) with CHF and dyssynchrony were randomized to CRT with (n=8) or without (n=9) ET and compared with two matched control CHF groups (standard care with ET: n=9, standard care only: n=10). At baseline and after 5 months, exercise tolerance, left ventricular (LV) remodelling, QOL and NT-pro brain natriuretic peptide (NT-proBNP) levels were assessed. RESULTS: Peak oxygen consumption (VO2peak), maximal workload (Wattmax), circulatory power, LV ejection fraction, dyssynchrony and QOL improved in both CRT groups. However, the increase in VO2peak (+40% versus +16%, P=0.005), Wattmax (+43% versus +13%, P=0.0005), and circulatory power (+74% versus +32%, P=0.01), was significantly greater in the trained versus the untrained CRT patients. Comparison of the four patient groups confirmed the cumulative effects of CRT plus ET. CONCLUSIONS: ET in resynchronized CHF patients is feasible and further enhances exercise tolerance. Patients with severe CHF should be prescribed an exercise training programme after implantation in order to maximize the expected benefit. |
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Authors:
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Viviane M A Conraads; Marc Vanderheyden; Bernard Paelinck; Sofie Verstreken; Ivan Blankoff; Hielko Miljoen; Johan De Sutter; Paul Beckers |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 14 ISSN: 1741-8267 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-15 Completed Date: 2007-05-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 99-106 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Hospital Antwerp, Wilrijkstraat, Belgium. Viviane.Conraads@uza.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bundle-Branch Block / therapy* Cardiac Output, Low / therapy*, ultrasonography Cardiac Pacing, Artificial* Chronic Disease Electric Countershock* Exercise Tolerance Female Humans Male Middle Aged Natriuretic Peptide, Brain / blood Peptide Fragments / blood Physical Endurance* Pilot Projects Pulmonary Gas Exchange Quality of Life Ventricular Dysfunction, Left / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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