| The effect of endotoxin on alcohol dehydrogenase (ADH) activity in the serum of ethanol intoxicated rats. | |
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MedLine Citation:
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PMID: 7497088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum alcohol dehydrogenase activity at different pH-values (8.8, 9.6 and 10.4) was investigated in induced endotoxemia (3 mg/kg) after chronic alcohol consumption in rats (60 days, 11.5 mg/kg, per day). It has been shown that ADH activity is higher after the single than after the triple injection of endotoxin given the healthy rats. Such a difference was not observed in the ethanol-intoxicated rats. The single dose of endotoxin did not maintain the increased ADH activity after alcohol administration, however a triple injection of endotoxin maintained the activity but did not increase. This results show, that the highest ADH activity in all tested rats was observed at pH 9.6 and that chronic ethanol consumption did not cause an increase of the toxic effects of endotoxin on liver cells, measured by serum alcohol dehydrogenase activity. |
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Authors:
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L Chrostek; M Szmitkowski; A Hryniewicz; A Boroń-Kaczmarska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Roczniki Akademii Medycznej w Białymstoku (1995) Volume: 39 ISSN: - ISO Abbreviation: Rocz. Akad. Med. Bialymst. Publication Date: 1994 |
Date Detail:
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Created Date: 1996-01-17 Completed Date: 1996-01-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9515551 Medline TA: Rocz Akad Med Bialymst Country: POLAND |
Other Details:
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Languages: eng Pagination: 74-80 Citation Subset: IM |
Affiliation:
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Department of Biochemical Diagnostics, Medical Academy of Białystok. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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metabolism Alcohol Dehydrogenase / blood* Alcoholic Intoxication / enzymology* Animals Aspartate Aminotransferases / metabolism Endotoxins / toxicity* Escherichia coli* Hydrogen-Ion Concentration Liver / enzymology* Male Rats Rats, Wistar Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; EC 1.1.1.1/Alcohol Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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