Document Detail


The effect of enalapril and telmisartan on clinical and biochemical indices of sympathetic activity in hypertensive patients.
MedLine Citation:
PMID:  18633764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare the effect of ARB and ACE inhibitor on sympathetic activity in 32 hypertensives.
DESIGN AND METHODS: After a four-week wash-out period, patients were randomized to four weeks of therapy with enalapril or telmisrtan, with crossover to another drug for another four weeks. Blood pressure (BP), NPY, and catecholamine levels and HRV (frequency analysis) were measured during wash-out, in basal condition, and after postural stimulation test (PST).
RESULTS: Both drugs significantly reduced BP and NPY as compared to initial values, while no differences in BP and NPY between drugs were observed. Increase in NPY during PST was significantly higher in the enalapril than in the telmisartan group and during the wash-out period. No differences between enalapril and telmisartan in plasma catecholamines were observed. Telmisartan decreased low frequency/high frequency ratio as compared to initial values and enalapril values.
CONCLUSIONS: Despite similar BP control, telmisartan attenuated autonomic balance more effectively than enalapril.
Authors:
Jacek Lewandowski; Piotr Abramczyk; Anna Dobosiewicz; Joanna Bidiuk; Maciej Sinski; Zbigniew Gaciong
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  30     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-17     Completed Date:  2008-09-19     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angiotensin-Converting Enzyme Inhibitors / pharmacology*,  therapeutic use
Benzimidazoles / pharmacology*,  therapeutic use
Benzoates / pharmacology*,  therapeutic use
Blood Pressure / drug effects
Blood Pressure Monitoring, Ambulatory
Cross-Over Studies
Enalapril / pharmacology*,  therapeutic use
Epinephrine / blood
Female
Heart Rate / drug effects
Humans
Hypertension / diagnosis,  drug therapy*,  physiopathology
Male
Middle Aged
Neuropeptide Y / blood,  drug effects
Norepinephrine / blood
Posture / physiology
Sympathetic Nervous System / drug effects*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzimidazoles; 0/Benzoates; 0/Neuropeptide Y; 69PN84IO1A/Enalapril; U5SYW473RQ/telmisartan; X4W3ENH1CV/Norepinephrine; YKH834O4BH/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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