| The effect of enalapril and telmisartan on clinical and biochemical indices of sympathetic activity in hypertensive patients. | |
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MedLine Citation:
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PMID: 18633764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effect of ARB and ACE inhibitor on sympathetic activity in 32 hypertensives. DESIGN AND METHODS: After a four-week wash-out period, patients were randomized to four weeks of therapy with enalapril or telmisrtan, with crossover to another drug for another four weeks. Blood pressure (BP), NPY, and catecholamine levels and HRV (frequency analysis) were measured during wash-out, in basal condition, and after postural stimulation test (PST). RESULTS: Both drugs significantly reduced BP and NPY as compared to initial values, while no differences in BP and NPY between drugs were observed. Increase in NPY during PST was significantly higher in the enalapril than in the telmisartan group and during the wash-out period. No differences between enalapril and telmisartan in plasma catecholamines were observed. Telmisartan decreased low frequency/high frequency ratio as compared to initial values and enalapril values. CONCLUSIONS: Despite similar BP control, telmisartan attenuated autonomic balance more effectively than enalapril. |
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Authors:
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Jacek Lewandowski; Piotr Abramczyk; Anna Dobosiewicz; Joanna Bidiuk; Maciej Sinski; Zbigniew Gaciong |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 30 ISSN: 1525-6006 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-17 Completed Date: 2008-09-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 423-32 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiotensin-Converting Enzyme Inhibitors / pharmacology*, therapeutic use Benzimidazoles / pharmacology*, therapeutic use Benzoates / pharmacology*, therapeutic use Blood Pressure / drug effects Blood Pressure Monitoring, Ambulatory Cross-Over Studies Enalapril / pharmacology*, therapeutic use Epinephrine / blood Female Heart Rate / drug effects Humans Hypertension / diagnosis, drug therapy*, physiopathology Male Middle Aged Neuropeptide Y / blood, drug effects Norepinephrine / blood Posture / physiology Sympathetic Nervous System / drug effects* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzimidazoles; 0/Benzoates; 0/Neuropeptide Y; 144701-48-4/telmisartan; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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