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The effect of embryo and maternal genotypes on prolificacy, intrauterine growth retardation and postnatal development of Nos3-knockout mice.
MedLine Citation:
PMID:  21113205     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Mice deficient for endothelial nitric oxide synthase (NOS3(-/-)) may represent a good model for studying embryo loss and intrauterine growth retardation caused by vascular deficiencies. We determined the effects of embryo genotype (homozygous vs. heterozygous descendants with paternal or maternal source of the non-functional NOS3 allele) and maternal environment (NOS3(-/-) vs. wild-type NOS3(+/+) females) on the appearance of estrus, fertility and prolificacy rates and live weight in the first week of life as well as phenotypic characteristics of offspring during the postnatal period. The results indicated that pregnancy outcomes and postnatal development of NOS3(-/-) mice seem to be related to deficiencies in fetal programming mainly determined by maternal genotype.
Authors:
Pilar Pallares; Antonio Gonzalez-Bulnes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive biology     Volume:  10     ISSN:  1642-431X     ISO Abbreviation:  Reprod Biol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160559     Medline TA:  Reprod Biol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  241-8     Citation Subset:  IM    
Affiliation:
Animal Reproduction Department, INIA, Av. Puerta de Hierro s/n. 28040-Madrid, Spain; e-mail: pallares.pilar@inia.es.
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