Document Detail


The effect of eicosapentaenoic acid on renal function and volume in patients with ADPKD.
MedLine Citation:
PMID:  18372389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Soy protein ameliorates rat polycystic kidney disease with concomitant renal enrichment of omega3-polyunsaturated fatty acids. A study was conducted to examine the effects of eicosapentaenoic acids (EPA) on renal volume and function in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS: Non-azotemic patients were randomized to either a control group (n = 20) or an EPA group (n = 21). EPA capsules (2.4 g/day) were administered in the EPA group for 2 years. Twenty-four hours of urine was collected for the creatinine clearance (Ccr) measurement every year. At baseline and 24 months, fatty acid compositions in erythrocytes were measured and computerized tomographies were obtained for calculation of renal volume by the modified ellipsoid and volumetric methods. RESULTS: In the EPA group, the EPA concentration (1.80 +/- 0.99 versus 4.40 +/- 1.79 area%, P < 0.001) and the omega3/omega6 ratio in the erythrocyte increased, but docosahexaenoic acid (DHA) (6.76 +/- 1.19 versus 5.64 +/- 1.45 area%, P < 0.010) concentration decreased. Ccr decreased by 8.5 +/- 9.5 and 9.0 +/- 13.0 ml/min/1.73 m(2)/2 years in the control and EPA groups, respectively (NS). The increases in renal volume calculated by either method were not significantly different between the two groups. CONCLUSIONS: A beneficial effect of EPA on renal function and kidney volume in ADPKD patients could not be confirmed in the present study. Administration of EPA with DHA supplementation and/or longer intervention might be necessary to demonstrate preventive effects of omega3-polyunsaturated fatty acids on progression of ADPKD.
Authors:
Eiji Higashihara; Kikuo Nutahara; Shigeo Horie; Satoru Muto; Tatsuo Hosoya; Kazushige Hanaoka; Ken Tuchiya; Kouichi Kamura; Kenmei Takaichi; Yoshifumi Ubara; Miho Itomura; Tomohito Hamazaki
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-03-27
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  23     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-19     Completed Date:  2009-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  2847-52     Citation Subset:  IM    
Affiliation:
Department of Urology, Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, Japan. ehigashi@kyorin-u.ac.jp
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00541853
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Creatinine / urine
Disease Progression
Eicosapentaenoic Acid / pharmacology*,  therapeutic use
Erythrocytes / chemistry
Female
Humans
Kidney / drug effects*
Male
Middle Aged
Organ Size / drug effects
Polycystic Kidney, Autosomal Dominant / drug therapy,  physiopathology*
Prospective Studies
Young Adult
Chemical
Reg. No./Substance:
1553-41-9/Eicosapentaenoic Acid; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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