Document Detail


The effect of early postnatal hypoxia on the regional cerebral utilization of glucose in adult rats.
MedLine Citation:
PMID:  3241608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to establish if there are any later changes in the local cerebral energy metabolism after exposing 1-day-old rats for 5 days (10 hr daily) to hypobaric hypoxia (pO2 = 10.5 kPa). For this study the 2-[14C]deoxyglucose method for the determination of the regional utilization of glucose in the rat brain was employed. The results, obtained in 41 cerebral structures, show that rats subjected to an early postnatal hypoxia exhibit a significant decrease (-41%) 3 months later in the utilization of glucose in the CA, area of the hippocampus. This finding is a new one in the chain of several biochemical and behavioral changes observed in this experimental model. It is suggested that this finding could be useful in the search for a new therapeutic agent eventually able to alleviate the consequences of perinatal hypoxia.
Authors:
V Stefanovich; A Lun; J Gross
Related Documents :
8091478 - The effects of aging and nutritional state on hypoxia-reoxygenation injury in the perfu...
3251898 - Enhanced glucose metabolism and impaired placental function in hypoxic pregnant rats.
15299038 - Structural and functional adaptation to hypoxia in the rat brain.
7404848 - Evidence for gas nuclei in decompressed rats.
570178 - Morphometric study of testicle alterations in rats submitted to hypervitaminosis a.
6753428 - Prostacyclin and prostaglandin synthesis in rat brain microvessels: characteristic chan...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolic brain disease     Volume:  3     ISSN:  0885-7490     ISO Abbreviation:  Metab Brain Dis     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-05-12     Completed Date:  1989-05-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  311-5     Citation Subset:  IM    
Affiliation:
Hoechst AG, Wiesbaden, FRG.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / metabolism*
Anoxia / metabolism*,  physiopathology
Brain / metabolism*,  physiopathology
Glucose / metabolism*
Male
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Polyamine metabolism in reversible cerebral ischemia of Mongolian gerbils.
Next Document:  Palindrome-hairpin linear plasmids possessing only a part of the ORF1 gene of the yeast killer plasm...