| The effect of early fetal losses on twin assisted-conception pregnancy outcomes. | |
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MedLine Citation:
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PMID: 18804206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of first trimester fetal losses on twin births from assisted reproductive technology (ART). DESIGN: Historical cohort study. SETTING: Clinic-based data. PATIENT(S): The study population included 9,036 twin pregnancies of >or=22 weeks' gestation in the 2005 Society for Assisted Reproductive Technology Clinic Outcomes Reporting System database, categorized by the presence of three versus two fetal heartbeats on early ultrasound. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Length of gestation and birthweight. Adjusted odds ratios (AORs) were calculated with the group with two fetal heartbeats on early ultrasound as the reference. RESULT(S): Increased odds with three fetal heartbeats included <32 weeks, 32-36 weeks, and <37 weeks (AORs 1.47, 1.28, and 1.35, respectively) and very low birthweight (<1,500 g), moderately low birthweight (1,500-2,499 g), and low birthweight (<2,500 g) (AORs 1.69, 1.38, and 1.47, respectively). Significantly decreased odds included term birth (>or=37 weeks) and nonlow birthweight (>or=2,500 g) (AORs 0.74 and 0.68). CONCLUSION(S): Early fetal loss in assisted-conception pregnancies that result in a twin live birth is associated with significantly increased risks for lowered birthweight and shortened gestation. Because first-trimester multiple fetal heartbeats are more common in ART pregnancies, this factor may help explain the greater risk for reduced birthweight and shorter gestations observed in this population. |
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Authors:
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Barbara Luke; Morton B Brown; David A Grainger; Judy E Stern; Nancy Klein; Marcelle I Cedars |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-18 |
Journal Detail:
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Title: Fertility and sterility Volume: 91 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2586-92 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, Michigan 48824, USA. lukeb@msu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight Cohort Studies Female Fetal Death Heart Rate, Fetal Humans Infant, Low Birth Weight Infant, Newborn Infant, Very Low Birth Weight Maternal Age Middle Aged Odds Ratio Pregnancy Pregnancy Outcome / psychology* Pregnancy Trimester, First Pregnancy Trimester, Third Reference Values Reproductive Techniques, Assisted / psychology* Twins Ultrasonography, Prenatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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