| The effect of dynamic vessel motion on haemodynamic parameters in the right coronary artery: a combined MR and CFD study. | |
| | |
MedLine Citation:
|
PMID: 20348532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Human right coronary artery (RCA) haemodynamics is investigated using computational fluid dynamics (CFD) based on subject-specific information from magnetic resonance (MR) acquisitions. The dynamically varying vascular geometry is reconstructed from MR images, incorporated in CFD in conjunction with pulsatile flow conditions obtained from MR velocity mapping performed on the same subject. The effects of dynamic vessel motion on instantaneous and cycle-averaged haemodynamic parameters, such as wall shear stress (WSS), time-averaged WSS (TAWSS) and oscillatory shear index (OSI), are examined by comparing an RCA model with a time-varying geometry and those with a static geometry, corresponding to nine different time-points in the cardiac cycle. The results show that the TAWSS is similar for the dynamic and static wall models, both qualitatively and quantitatively (correlation coefficient 0.89-0.95). Conversely, the OSI shows much poorer correlations (correlation coefficient 0.38-0.60), with the best correspondence being observed with the static models constructed from images acquired in late diastole (at t = 0 and 800 ms, the cardiac cycle is 900 ms). These findings suggest that neglecting dynamic motion of the RCA is acceptable if TAWSS is the primary focus but may result in underestimation of haemodynamic parameters related to the oscillatory nature of the blood flow. |
| | |
Authors:
|
R Torii; J Keegan; N B Wood; A W Dowsey; A D Hughes; G-Z Yang; D N Firmin; S A Mcg Thom; X Y Xu |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The British journal of radiology Volume: 82 Spec No 1 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2010-03-29 Completed Date: 2010-07-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
|
Languages: eng Pagination: S24-32 Citation Subset: AIM; IM |
Affiliation:
|
Department of Chemical Engineering, Imperial College, London, UK. r.torii@imperial.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Flow Velocity / physiology Coronary Vessels / anatomy & histology, physiology* Hemodynamics Hemorheology / physiology Humans Image Processing, Computer-Assisted / methods Magnetic Resonance Angiography / methods Male Models, Cardiovascular Motion Pulsatile Flow / physiology Stress, Mechanical |
| Grant Support | |
ID/Acronym/Agency:
|
PG/04/078//British Heart Foundation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Computational analysis of oxygen transport in a patient-specific model of abdominal aortic aneurysm ...
Next Document: Three-dimensional imaging and computational modelling for estimation of wall stresses in arteries.