| The effect of drinking intensity and frequency on serum carbohydrate-deficient transferrin and gamma-glutamyl transferase levels in outpatient alcoholics. | |
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MedLine Citation:
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PMID: 9802528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whereas heavy alcohol consumption is known to elevate serum carbohydrate-deficient transferrin (CDT) and gamma-glutamyl transferase (GGT) levels, the contribution of drinking pattern to these effects is not completely understood. We present data on 423 men and 146 women evaluated 1 year after treatment in a large-scale alcoholism treatment study (Project MATCH). Relationships between drinking frequency (number of days drinking), intensity (drinks per drinking day), and blood levels of CDT and GGT were analyzed by using response surface regression models and thin-plate spline-smoothing techniques. Both models indicated differences between CDT- and GGT-drinking pattern relationships in men and, also, a difference between men and women in CDT drinking-pattern relationships. For men, CDT levels appeared to respond primarily to frequency of drinking, whereas GGT was influenced primarily by drinking intensity. For women, both CDT and GGT were influenced more by drinks per drinking day (intensity) than by number of days drinking (frequency). The data confirm both the independent nature of these biological markers of alcohol consumption and gender differences in alcohol-induced CDT response reported previously. |
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Authors:
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R F Anton; R L Stout; J S Roberts; J P Allen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 22 ISSN: 0145-6008 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-02-04 Completed Date: 1999-02-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1456-62 Citation Subset: IM |
Affiliation:
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Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking / adverse effects* Alcoholism / diagnosis*, enzymology, rehabilitation Ambulatory Care Biological Markers / blood Female Humans Liver Function Tests* Male Middle Aged Psychotherapy / methods Transferrin / analogs & derivatives*, metabolism gamma-Glutamyltransferase / blood* |
| Grant Support | |
ID/Acronym/Agency:
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2U10AA08428/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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