Document Detail

The effect of dressing with fresh kiwifruit on burn wound healing.
MedLine Citation:
PMID:  20381106     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was designed to evaluate the wound healing effects of kiwifruit in the treatment of second-degree burn wounds in rats. METHODS: Sixty rats were each randomly assigned to 1 of 3 groups. A deep second-degree burn was created on the lateral flank of each rat with a standard burning procedure in the form of applying a heated plaque. In the control group (group C; n = 20) burns were dressed with Vaseline sterile gauze after normal saline irrigation. In group S (n = 20), the lesions were treated with silver sulfadiazine cream after normal saline irrigation. In the third group (group K; n = 20), the burn wounds were dressed with kiwifruit. The dressings were changed twice a day in all groups. The response to treatments was assessed histologically at day 21 postburn and microbiologically on days 7 and 21. Macroscopic evaluation was performed every day to determine wound closure rate, measure burn wound area, and investigate macroscopic edema, hyperemia, and epithelialization. Histopathologic evaluation included monitoring of epithelialization, vascularization, granulation tissue formation, and inflammatory cell response. RESULTS: On day 21, the wounds in the group K healed completely in comparison to other groups (P < .0001). There was significant reduction in wound area size in the group K in all evaluation days as compared with groups S and C (P < .0001). Microscopic evaluation revealed a high grade of neovascularization in group K lesions in contrast with groups S and C (P < .0001). Wound infection was dramatically less common in the group K compared with the other 2 groups (P < .05). CONCLUSION: We suggest that the dramatic antibacterial, debridement, wound contracture, and angiogenic effect of kiwifruit induced a significant wound healing in burn ulcers and might be useful in treating chronic ulcers, such as bedsores.
Gholamreza Mohajeri; Hassan Masoudpour; Mitra Heidarpour; Elham Fatemeh Khademi; Shahab Ghafghazi; Shahriar Adibi; Mojtaba Akbari
Related Documents :
18028126 - Randomized, multicenter, double-blind, and placebo-controlled trial using topical recom...
20734046 - Local administration of antibiotics by gentamicin-collagen sponge does not improve woun...
12540076 - Perioperative complications of total ankle arthroplasty.
23997736 - Expression of inducible nitric oxide synthase in muscle flaps treated with ischemic pos...
2377446 - The role of danazol in the treatment of refractory idiopathic thrombocytopenic purpura....
22971306 - Propranolol in the treatment of problematic infantile hemangioma: review of 35 consecut...
Publication Detail:
Type:  Journal Article     Date:  2010-04-08
Journal Detail:
Title:  Surgery     Volume:  148     ISSN:  1532-7361     ISO Abbreviation:  Surgery     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2010-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  963-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Thoracic Surgery Department, Isfahan University of Medical Sciences, Isfahan, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Burns / microbiology,  pathology,  therapy*
Rats, Wistar
Silver Sulfadiazine / therapeutic use
Wound Healing*
Reg. No./Substance:
22199-08-2/Silver Sulfadiazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Serum and intratumoural GH and IGF-I concentrations: Prognostic factors in the outcome of canine mam...
Next Document:  Comparable results with 3-year follow-up for large-pore versus small-pore meshes in open incisional ...