Document Detail


The effect of the doxycycline-rifampicin and levamisole combination on lymphocyte subgroups and functions of phagocytic cells in patients with chronic brucellosis.
MedLine Citation:
PMID:  15722630     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Brucellosis is one of the important health problems for both humans and animals in Turkey since agriculture and stock raising appears to be the most important means of subsistence. Investigations on the pathogenesis of brucellosis reveal that the etiologic agent can survive in phagocytic cells, and cell-mediated immunity plays an important role in immunity against bacteria. METHODS: In this study, we investigated whether supplementation of levamisole, a well-known antihelminthic agent with immune-stimulating activity to conventional antibiotic therapy, would improve the anergy against Brucella. RESULTS: The results of our study reveal that a 6-week course of levamisole as a supplement to conventional antibiotic therapy in chronic brucellosis is not superior to conventional antibiotic treatment alone with respect to lymphocyte subgroup ratios and phagocytic function. CONCLUSION: In chronic brucellosis, levamisole administered as a supplement concomitantly with conventional antibiotic therapy has no immunostimulating effect on the basis of the lymphocyte subgroups ratios measured and the ability of phagocytosis in the present study. Further large clinical and laboratory trials are necessary to investigate the immunological and physiological effects of levamisole on T(H1) subtypes and cytokine secretion.
Authors:
Ufuk Dizer; Levent Hayat; Can Murat Beker; Levent Görenek; Volkan Ozgüven; Alaaddin Pahsa
Publication Detail:
Type:  Journal Article     Date:  2005-02-17
Journal Detail:
Title:  Chemotherapy     Volume:  51     ISSN:  0009-3157     ISO Abbreviation:  Chemotherapy     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-04-06     Completed Date:  2005-07-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  27-31     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel.
Affiliation:
Department of Infectious Diseases and Clinical Microbiology, Gulhane Military Medical Academy, Ankara, Turkey. ufukdizer@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Brucella melitensis / pathogenicity
Brucellosis / drug therapy*,  epidemiology,  immunology
Chronic Disease
Combined Modality Therapy
Doxycycline / pharmacology*
Drug Therapy, Combination / pharmacology*
Female
Humans
Immunity, Cellular
Levamisole / pharmacology*
Lymphocytes / classification,  drug effects*
Male
Phagocytosis / drug effects*
Rifampin / pharmacology*
Turkey
Chemical
Reg. No./Substance:
13292-46-1/Rifampin; 14769-73-4/Levamisole; 564-25-0/Doxycycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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