Document Detail

The effect of dose on maternal-foetal transfer of fluoride in rabbits.
MedLine Citation:
PMID:  1854264     Owner:  NLM     Status:  MEDLINE    
Placental transfer of fluoride was investigated by fluoride determination in the bones and teeth of newborn rabbits whose mothers had been treated with fluoride during pregnancy. The mothers were given doses of 0, 0.10, 0.52 and 1.05 mmol fluoride per kg body weight as sodium fluoride, from the 16th day after conception to the end of pregnancy. All the doses produced a significant increase of fluoride level in the bones and teeth of newborn rabbits, indicating that the placenta was no barrier for the passage of fluoride.
M Nedeljković; V Matović
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arhiv za higijenu rada i toksikologiju     Volume:  42     ISSN:  0004-1254     ISO Abbreviation:  Arh Hig Rada Toksikol     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-08-21     Completed Date:  1991-08-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0373100     Medline TA:  Arh Hig Rada Toksikol     Country:  YUGOSLAVIA    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Department of Toxicological Chemistry, School of Pharmacy, University of Belgrade, Yugoslavia.
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MeSH Terms
Animals, Newborn / metabolism
Bone and Bones / metabolism
Dose-Response Relationship, Drug
Maternal-Fetal Exchange*
Sodium Fluoride / administration & dosage,  pharmacokinetics*
Tooth / metabolism
Reg. No./Substance:
7681-49-4/Sodium Fluoride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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