Document Detail


The effect of dopamine on the intraocular pressure and pupil of the rabbit eye.
MedLine Citation:
PMID:  1262169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence of a dopamine-specific receptor that can influence intraocular pressure in the rabbit eye is suggested by these experiments: intravitreal, systemic, or topically administered dopamine solutions can produce a decrease in intraocular pressure that is dose-dependent. In high doses the decrease in intraocular pressure is accompanied by mydriasis, and alpha-adrenergic pupillary response. This alpha-response may be caused by dopamine as a direct, but weak alpha-stimulator or by displacement of norepinephrine onto the receptor from its storage site. At lower doses the decrease in intraocular pressure occurs in the absence of mydriasis and in spite of blockade of beta-adrenergic receptors. Further, a specific dopaminergic blocker, haloperidol, prevents this decrease in intraocular pressure. The decreases are small, but reproducible and suggest that dopamine can influence the adrenergic regulation of intraocular pressure.
Authors:
R P Shannon; A Mead; M L Sears
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Investigative ophthalmology     Volume:  15     ISSN:  0020-9988     ISO Abbreviation:  Invest Ophthalmol     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374730     Medline TA:  Invest Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  371-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Animals
Denervation
Dopamine / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Ganglia, Autonomic / physiology
Haloperidol / pharmacology
Intraocular Pressure / drug effects*
Male
Propranolol / administration & dosage
Pupil / drug effects*
Rabbits
Chemical
Reg. No./Substance:
52-86-8/Haloperidol; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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