Document Detail

The effect of dopamine in a model of biliary acute hemorrhagic pancreatitis.
MedLine Citation:
PMID:  1876597     Owner:  NLM     Status:  MEDLINE    
Perfusion of the main pancreatic duct in cats with a dilute solution of bile salts increases ductal permeability. Subsequent perfusion of a permeable duct with activated pancreatic enzymes results in acute edematous pancreatitis. Simultaneous infusion of 16-16 dimethyl-PgE2 converts edematous pancreatitis to acute hemorrhagic pancreatitis (AHP). AHP may be associated with a reduction in pancreatic blood flow; it is certainly associated with increases in microvascular permeability. Low dose dopamine is a splanchnic vasodilator and may also reduce pancreatic microvascular permeability through beta agonist effects. In these studies, we investigated the effect of dopamine in an established feline model of biliary AHP. We also studied its effect on blood flow in both normal pancreas and after induction of AHP. We found that dopamine significantly reduced the degree of pancreatic inflammation, even when administered up to 12 h after onset of biliary AHP. However, the drug had no significant effect on blood flow either in normal pancreas or in the gland affected by hemorrhagic pancreatitis. We concluded that the effect of dopamine was most likely due to its ability to reduce pancreatic microvascular permeability.
N D Karanjia; A L Widdison; F J Lutrin; H A Reber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  6     ISSN:  0885-3177     ISO Abbreviation:  Pancreas     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-09-20     Completed Date:  1991-09-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  392-7     Citation Subset:  IM    
Department of Surgery, VA Medical Center, Sepulveda, CA 91343.
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MeSH Terms
16,16-Dimethylprostaglandin E2 / administration & dosage,  pharmacology
Acute Disease
Biliary Tract Diseases / complications,  physiopathology*
Capillary Permeability / drug effects
Disease Models, Animal
Dopamine / pharmacology*
Infusions, Intravenous
Pancreas / blood supply,  drug effects,  physiology
Pancreatitis / chemically induced,  physiopathology*
Regional Blood Flow / drug effects
Reg. No./Substance:
39746-25-3/16,16-Dimethylprostaglandin E2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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