| The effect of dobutamine on blood flow of free tissue transfer flaps during head and neck reconstructive surgery*. | |
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MedLine Citation:
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PMID: 19735400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SUMMARY: In view of the controversy over the use of inotropes in free tissue transfer surgery, we assessed the effect of different intra-operative dobutamine infusion rates on blood flow in the anastomosed recipient artery. Twenty patients undergoing head and neck tumour resection and immediate reconstructive surgery with free tissue transfer were recruited. After completion of the microvascular anastomoses, patients received dobutamine infusions of 2, 4 and 6 microg x kg(-1) x min(-1) in a randomised order. After steady state dobutamine concentration was achieved, mean and maximum blood flow in the arterial anastomosis was measured at each concentration, using the Medi-Stim Butterfly Flowmeter system. Systemic haemodynamic parameters were simultaneously recorded using a pulse contour cardiac output system. Both mean and maximum blood flow increased significantly in the anastomosed artery at dobutamine infusions of 4 and 6 microg x kg(-1) x min(-1) and this was accompanied by increased cardiac output. This may improve free flap perfusion. |
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Authors:
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A Scholz; S Pugh; M Fardy; M Shafik; J E Hall |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anaesthesia Volume: 64 ISSN: 1365-2044 ISO Abbreviation: - Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-08 Completed Date: 2009-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 1089-93 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia and Intensive Care Medicine,University Hospital of Wales, Cardiff, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiotonic Agents / administration & dosage, pharmacology* Dobutamine / administration & dosage, pharmacology* Dose-Response Relationship, Drug Female Head and Neck Neoplasms / surgery* Hemodynamics / drug effects Humans Intraoperative Care / methods Male Microcirculation / drug effects Microsurgery Middle Aged Reconstructive Surgical Procedures / methods* Surgical Flaps / blood supply* |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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