Document Detail


The effect of d,l-methamphetamine on simulated driving performance.
MedLine Citation:
PMID:  21842157     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
RATIONALE: Illicit drugs such as methamphetamine are commonly abused drugs that have also been observed to be prevalent in drivers injured in road accidents. The exact effect of methamphetamine or its specific isomers on driving and driving behaviour have yet to be thoroughly investigated. METHODS: Twenty healthy recreational illicit stimulant users (ten males, ten females), aged between 21 and 34 years (mean = 24.3 years, SD = 3.4 years), attended two testing sessions involving oral consumption of 0.42 mg/kg d,l-methamphetamine or a matching placebo. The drug administration was counterbalanced, double-blind, and medically supervised. At each session, driving performance was assessed 2.5 h post-drug administration. RESULTS: Mean blood and saliva d,l-methamphetamine concentrations of approximately 90 and 400 ng/ml, respectively, at 2 h and 95 and 475 ng/ml at 3 h were observed. These levels of d,l-methamphetamine were found not to significantly impair, or improve, driving performance at the 2.5-h post-drug administration time point. CONCLUSIONS: The findings of this study illustrate that d,l-methamphetamine has no significant effect on simulated driving performance.
Authors:
Beata Y Silber; Rodney J Croft; Luke A Downey; David A Camfield; Katherine Papafotiou; Phillip Swann; Con Stough
Related Documents :
20072927 - Characterization of the antioxidant properties of pentaerithrityl tetranitrate (petn)-i...
21785697 - Short communication: in vitro efficacy testing of praziquantel, ivermectin, and oxfenda...
20924667 - Pharmacologic modulation of parasympathetic activity in heart failure.
21887897 - An autopsy case of multiple psychotropic drug poisoning.
25211217 - Sensitivity and specificity of multiple kato-katz thick smears and a circulating cathod...
17957277 - Molecular pathology and pharmacogenomics in alzheimer's disease: polygenic-related effe...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-13
Journal Detail:
Title:  Psychopharmacology     Volume:  -     ISSN:  1432-2072     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cumulative ionizing radiation exposure in patients with end stage kidney disease: a 6-year retrospec...
Next Document:  A diffusion model decomposition of the effects of alcohol on perceptual decision making.