Document Detail

The effect of diterpenoidic diacylglycerols on tentacle regeneration in Hydra vulgaris.
MedLine Citation:
PMID:  1687559     Owner:  NLM     Status:  MEDLINE    
1. The effect of two ichthyotoxic diterpenoid diacylglycerols, verrucosins A and B, previously isolated from the mantle of a marine nudibranch mollusc, were studied on Hydra vulgaris tentacle regeneration. 2. A potent effect was found for both verrucosins in the low nanomolar range; the rank of potency observed was analogous to that reported for diglycerid activation of protein kinase C and to that found for verrucosin activation of this enzyme. 3. In the high nanomolar range, the two verrucosins were found to be toxic to Hydra vulgaris. 4. Verrucosin B-induced toxicity and tentacle regeneration were found to be dependent on [Ca2+] in the assay medium.
L De Petrocellis; V Di Marzo; B Arcà; M Gavagnin; R Minei; G Cimino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology     Volume:  100     ISSN:  0742-8413     ISO Abbreviation:  Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-06-18     Completed Date:  1992-06-18     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8310013     Medline TA:  Comp Biochem Physiol C     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  603-7     Citation Subset:  IM    
Istituto di Cibernetica del Consiglio Nazionale delle Ricerche, Arco Felice, Italy.
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MeSH Terms
Diglycerides / pharmacology*
Diterpenes / pharmacology*
Dose-Response Relationship, Drug
Hydra / drug effects*
Regeneration / drug effects*
Reg. No./Substance:
0/Diglycerides; 0/Diterpenes; 115712-99-7/verrucosin B; 115713-02-5/verrucosin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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