Document Detail

The effect of discontinuing dehydroepiandrosterone supplementation on Zucker rat food intake and hypothalamic neurotransmitters.
MedLine Citation:
PMID:  8520638     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Dehydroepiandrosterone (DHEA) decreases body weight and food intake of the obese Zucker rat, a model of youth-onset obesity associated with hyperphagia. The effects of discontinuing DHEA treatment on these parameters, however, has not been investigated. This question was studied in rats that had been maintained on DHEA-supplemented (0.0%, 0.06%, 0.15%, 0.3% or 0.6%) diets for 7 days.
METHOD: The results were correlated with regional levels of hypothalamic neurotransmitters in rats treated with 0.6% DHEA for 7 days in a separate experiment. Neurotransmitter changes were evaluated after Day 0 (7 days of treatment), and Day +1 and Day+2 post-DHEA.
RESULTS: Upon removing dietary DHEA, rats immediately (+1 day) consumed significantly more food than while on the DHEA-supplemented diet. Indeed, they consumed even more food than the group that had always been on the DHEA-free diet. This intake above control lasted for as long as +9 days post-DHEA treatment. After 7 days of DHEA treatment, lateral hypothalamic (LH) serotonin (5-HT) and dopamine (Dpm) were elevated significantly (P < 0.05) immediate changes in 5-HT and Dpm returned to baseline by day 2 of post-DHEA treatment. No significant changes occurred in either the ventromedial hypothalamus (VMH) or the paraventricular nucleus (PVN).
CONCLUSIONS: These observations suggest that there is a possible relationship between increases of LH 5-HT and Dpm with 0.6% DHEA treatment. Both are inhibitory to food intake and DHEA at the 0.6% dose causes hypophagia after 7 days of treatment (i.e. 0 days). Subsequent decreases of these monoamines occurred during the post-DHEA period at both +1 and +2 days. Return of these inhibitory monoamines to baseline could be responsible for reversal of the hypophagia, however, they do not rule out the production of a separate stimulator of food intake.
J R Porter; J M Abadie; B E Wright; E S Browne; F Svec
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  19     ISSN:  -     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-01-24     Completed Date:  1996-01-24     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  480-8     Citation Subset:  IM    
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MeSH Terms
Androstenedione / blood
Body Weight / physiology
Dehydroepiandrosterone / administration & dosage,  blood,  pharmacology*
Disease Models, Animal
Dopamine / analysis,  blood,  physiology
Eating / physiology*
Energy Intake / physiology
Food, Fortified
Hydroxyindoleacetic Acid / blood,  metabolism
Hypothalamus / chemistry,  metabolism,  physiology*
Neurotransmitter Agents / analysis,  blood*,  physiology
Norepinephrine / blood,  metabolism
Obesity / blood,  physiopathology
Rats, Zucker
Serotonin / analysis,  blood,  physiology
Testosterone / blood
Reg. No./Substance:
0/Neurotransmitter Agents; 333DO1RDJY/Serotonin; 3XMK78S47O/Testosterone; 409J2J96VR/Androstenedione; 459AG36T1B/Dehydroepiandrosterone; 54-16-0/Hydroxyindoleacetic Acid; VTD58H1Z2X/Dopamine; X4W3ENH1CV/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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