Document Detail

The effect of direct autonomic nerve stimulation on left ventricular force in the isolated innervated Langendorff perfused rabbit heart.
MedLine Citation:
PMID:  16455307     Owner:  NLM     Status:  MEDLINE    
The relative contribution of the chronotropic effects of stimulating sympathetic and vagus nerves on cardiac inotropic changes in the isolated Langendorff perfused rabbit heart with intact dual autonomic nerves was studied. The force-frequency relationship was investigated, in addition to sympathetic nerve stimulation (SS) at 2 Hz (low), 5 Hz (med) and 10 Hz (high), and left and right vagus nerve stimulation (VS) studied at 2 Hz (low), 5 Hz (med) and 7 Hz (high) with and without right ventricular pacing. It was shown that a biphasic force-frequency relationship is present with a positive relationship at low heart rates and a negative force-frequency relationship at higher heart rates. There was a trend for left- and right-VS to decrease left ventricular pressure with a decrease in heart rate, whilst SS had the opposing effects in a frequency-dependent manner. When heart rate was kept constant, there was no effect from left- or right-VS, while SS increased left ventricular pressure in a frequency-dependent manner. Together these results suggest that SS, left- and right-VS alter left ventricular force by two different mechanisms. Left- and right-VS decrease left ventricular pressure predominantly via chronotropic effects whilst SS increases force predominantly by direct changes in contractility.
Kieran E Brack; John H Coote; G André Ng
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-07
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  124     ISSN:  1566-0702     ISO Abbreviation:  Auton Neurosci     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-28     Completed Date:  2006-05-12     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  69-80     Citation Subset:  IM    
Department of Physiology, Division of Medical Sciences, University of Birmingham, Medical School, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
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MeSH Terms
Autonomic Nervous System / physiology*
Electric Stimulation
Heart / innervation,  physiology*
Myocardial Contraction / physiology
Nerve Fibers / physiology
Neurons, Efferent / physiology
Vagus Nerve / cytology,  physiology
Ventricular Function, Left / physiology*

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