Document Detail

The effect of diltiazem, a calcium channel-blocking drug, on cardiac rate and rhythm in hyperthyroid patients.
MedLine Citation:
PMID:  2458079     Owner:  NLM     Status:  MEDLINE    
Tachycardia and tachyarrhythmias are frequent in patients with thyrotoxicosis, especially in the elderly. Since myocardial calcium uptake is increased in thyrotoxic rats, the efficacy of the calcium channel-blocking drug diltiazem in decreasing heart rate and the incidence of arrhythmias was evaluated in 11 hyperthyroid patients. All patients were studied with a 24-hour Holter monitor prior to the beginning of sole diltiazem therapy (120 mg given every eight hours), on the tenth day of therapy, and five days after therapy was discontinued. Heart rate significantly decreased by 17% during diltiazem treatment (96.5 +/- 3.7 systoles/min vs 79.9 +/- 3.2 systoles/min [mean +/- SE]) and returned to baseline values five days after the therapy was discontinued (100.7 +/- 3.4 systoles/min). Similarly, the number of premature ventricular extrasystoles per hour was significantly decreased (18 +/- 7 vs 2 +/- 1). In three patients, asymptomatic bouts of supraventricular tachycardia, paroxysmal atrial fibrillation, or ventricular tachycardia disappeared during diltiazem therapy. These findings suggest that calcium-blocking drugs may be extremely useful as adjunctive therapy for thyrotoxicosis in the presence of angina, congestive failure, and tachyarrhythmias.
E Roti; M Montermini; S Roti; E Gardini; G Robuschi; R Minelli; M Salvi; M Bentivoglio; U Guiducci; L E Braverman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  148     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-09-28     Completed Date:  1988-09-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1919-21     Citation Subset:  AIM; IM    
Cattedra di Endocrinologia e Patologia Costituzionale, Universita di Parma, Italy.
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MeSH Terms
Arrhythmias, Cardiac / blood,  drug therapy*,  physiopathology
Cardiac Complexes, Premature / blood,  drug therapy,  physiopathology
Diltiazem / administration & dosage,  pharmacology*,  therapeutic use
Drug Administration Schedule
Drug Evaluation
Heart Rate / drug effects*
Hyperthyroidism / blood,  drug therapy*,  physiopathology
Middle Aged
Thyroxine / blood
Triiodothyronine / blood
Triiodothyronine, Reverse / blood
Grant Support
Reg. No./Substance:
42399-41-7/Diltiazem; 5817-39-0/Triiodothyronine, Reverse; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine
Comment In:
Arch Intern Med. 1989 May;149(5):1217   [PMID:  2719517 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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