Document Detail

The effect of digoxin on the response to lithium therapy in mania.
MedLine Citation:
PMID:  6805000     Owner:  NLM     Status:  MEDLINE    
Patients suffering from manic-depressive psychosis, manic type (ICD 296.0), were treated with lithium carbonate and randomly allocated to two groups, one received digoxin and the other matching placebo for 7 days. Severity of mania was rated by psychiatrists on the Manic Rating Scale and Analogue Line on days 0 and 7 and by nurses daily on the Hargreaves Rating Scale, Psychotic Rating. Fourteen patients received digoxin and lithium carbonate and 14 patients received placebo and lithium carbonate. Improvement in the placebo lithium group was significantly greater than that in the digoxin lithium group. This trial suggests, therefore, that the effect of inhibition of membrane cation carrier is to reduce the response to lithium. This result is in keeping with our hypothesis that an increase in Na-K ATPase is essential to the therapeutic effect of lithium carbonate. It does not, however, exclude the possibility that the observations resulted from the inhibition by digoxin of lithium entry into the brain.
C A Chambers; A H Smith; G J Naylor
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Psychological medicine     Volume:  12     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-07-19     Completed Date:  1982-07-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
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MeSH Terms
Affective Disorders, Psychotic / drug therapy*
Bipolar Disorder / drug therapy*
Chlorpromazine / administration & dosage
Clinical Trials as Topic
Digoxin / administration & dosage*
Double-Blind Method
Drug Therapy, Combination
Lithium / administration & dosage*
Lithium Carbonate
Middle Aged
Nitrazepam / administration & dosage
Random Allocation
Reg. No./Substance:
146-22-5/Nitrazepam; 20830-75-5/Digoxin; 50-53-3/Chlorpromazine; 554-13-2/Lithium Carbonate; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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