Document Detail

The effect of digoxin on cardiovascular responses to hypoxia and reoxygenation in anesthetized dogs.
MedLine Citation:
PMID:  7106179     Owner:  NLM     Status:  MEDLINE    
To clarify the efficacy of digitalis in acute hypoxia and reoxygenation, we estimated the effects of digoxin on cardiovascular hemodynamics in anesthetized dogs. Hypoxia caused significant increases in aortic pressure, pulmonary artery pressure, left ventricular (LV) pressure, rate of change in LV pressure (LVdp/dt), cardiac output (CO) and plasma catecholamines. These changes in LVdp/dt, CO and plasma catecholamines induced by hypoxia were returned to the control levels within 3 min by reoxygenation with 70% O2. The injection of digoxin (0.05 mg/kg) in hypoxic dogs resulted in significant increases in LVdp/dt, CO and stroke volume (SV) but no changes in levels of plasma catecholamines, heart rate, mean aortic pressure and mean pulmonary artery pressure. However, the injection of digoxin resulted in no significant changes in cardiovascular response to reoxygenation. Our experiments demonstrate that digoxin caused significant increases in CO, SV and LVdp/dt in dogs with hypoxia but resulted in no significant changes in cardiovascular responses to reoxygenation.
K Saito; T Kashima; K Kiyonaga; H Tanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  80     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-10-21     Completed Date:  1982-10-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  237-42     Citation Subset:  IM    
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MeSH Terms
Anoxia / physiopathology*
Cardiovascular System / drug effects*
Catecholamines / blood
Digoxin / pharmacology*
Oxygen / pharmacology*
Reg. No./Substance:
0/Catecholamines; 20830-75-5/Digoxin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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