Document Detail

The effect of diflunisal on hyaluronic acid production by 'activated' human synovial fibroblasts.
MedLine Citation:
PMID:  7295473     Owner:  NLM     Status:  MEDLINE    
1 Cultured human synovial fibroblasts were 'activated' by leucocytes or poly (I) . poly (C) to overproduce hyaluronic acid. 2 Diflunisal in concentrations of 30, 15 and 10 microgram/ml completely abrogated the overproduction of hyaluronic acid induced by leucocytes. 3 Diflunisal (10 microgram/ml), indomethacin (2 microgram/ml) and aspirin (200 microgram/ml) partially inhibited the overproduction of hyaluronic acid induced by poly (I) . poly (C), although none of them decreased it to control non 'activated' levels. 4 Diflunisal 25 microgram/ml completely abrogated hyaluronic acid overproduction induced by poly (I) . poly (C). 5 This model could be an in vitro indicator for in vivo pharmacological levels of anti-inflammatory drugs.
M Yaron; I Yaron
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  12     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  423-6     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents / pharmacology
Cells, Cultured
Diflunisal / pharmacology*
Fibroblasts / metabolism
Hyaluronic Acid / biosynthesis*
Leukocytes / physiology
Poly I-C / pharmacology
Salicylic Acids / pharmacology*
Synovial Membrane / metabolism*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Salicylic Acids; 22494-42-4/Diflunisal; 24939-03-5/Poly I-C; 9004-61-9/Hyaluronic Acid

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