Document Detail

The effect of different nutritional states on cell-mediated cytotoxicity.
MedLine Citation:
PMID:  2373524     Owner:  NLM     Status:  MEDLINE    
We have studied the effect of acute short-term starvation (in 9 patients) and of prolonged caloric deprivation (in 10 patients with anorexia nervosa), on cell-mediated cytotoxicity (CMC). CMC became severely depressed after six days on a very low caloric diet (1.2 +/- 1.4 vs. 7.0 +/- 2.9 lytic units/10(6) cells; P less than 0.01). CMC was also low in our patients with anorexia nervosa compared to a matched control group (3.3 +/- 1.7 vs. 10.0 +/- 3.0 lytic units/10(6) cells; P less than 0.01) and increased in most of the patients studied (five cases) after the first 3-4 weeks of refeeding in correlation with weight gain. Dietary deprivation may lead to a significant impairment in cell-mediated cytotoxicity, which appears to be reversible after refeeding.
N Vaisman; T Hahn; Y Dayan; A Schattner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunology letters     Volume:  24     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:    1990 Mar-Apr
Date Detail:
Created Date:  1990-08-29     Completed Date:  1990-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  37-41     Citation Subset:  IM    
Department of Paediatrics, Kaplan Hospital, Rehovot, Israel.
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MeSH Terms
Analysis of Variance
Anorexia Nervosa / immunology*
Body Weight
Cytotoxicity, Immunologic / immunology*
Energy Intake
Hela Cells
Middle Aged
Nutritional Status*
Starvation / immunology

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