Document Detail


The effect of different apo(a) isoforms on plasminogen activation in black South African subjects.
MedLine Citation:
PMID:  12844195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The present study evaluates the effect of different apolipoprotein(a) [apo(a)] isofroms on plasminogen activation.
DESIGN: A cross-sectional study.
SETTING: A rural village (Dikgale district) in the Northen Province of South Africa.
SUBJECT: A total of 90 apparently healthy subjects (64 females and 36 males) aged 43 to 67 years participated in the study.
RESULTS: The mean lipoprotein(a) [ Lp(a)] level in the subjects was 38.14 +/- 22.34 mg/dl. No association was found between Lp(a) isoforms. When the ratio of Lp(a):plasminogen was less then 1.3, a competitive inhibition was observed, but when the ratio exceeded 1.3, an uncompetitive inhibition was observed with all isoforms.
CONCLUSION: The results of the present study suggest that the inhibition of plasminogen activation by Lp(a) is not dependent of apo(a) size.
Authors:
S R Choma; M Alberts; H C Potgieter; P J Ojwang
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners     Volume:  14     ISSN:  -     ISO Abbreviation:  Cardiovasc J S Afr     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-07-04     Completed Date:  2003-10-23     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  100964061     Medline TA:  Cardiovasc J S Afr     Country:  South Africa    
Other Details:
Languages:  eng     Pagination:  120-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group / genetics*
Aged
Apolipoproteins A / blood*
Cardiovascular Diseases / ethnology*,  genetics
Cross-Sectional Studies
Female
Humans
Hyperlipoproteinemias / ethnology*,  genetics
Lipoprotein(a) / blood*
Male
Middle Aged
Particle Size
Probability
Protein Isoforms
Risk Factors
Rural Population
South Africa / epidemiology
Tissue Plasminogen Activator / analysis,  metabolism*
Chemical
Reg. No./Substance:
0/Apolipoproteins A; 0/Lipoprotein(a); 0/Protein Isoforms; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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